cell-mediated cytotoxicity

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1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
References in periodicals archive ?
Combined with pathway analyses, 7 hot genes, except for B2M, participate in the TCR signaling pathway, and LCK, VAV1, IFNG, and TNF participate in the natural killer cell-mediated cytotoxicity pathway.
Moreover, recently, in vitro NK cell-mediated cytotoxicity was enhanced by type I interferon treatment in a model of NK-infected DC coculture [61], suggesting an important crosstalk between APCs and NK cells for viral clearance.
Avelumab is also thought to help white blood cells such as natural killer (NK) cells find and attack tumors in a process known as ADCC, or antibody-dependent cell-mediated cytotoxicity. In November 2014, Merck KGaA, Darmstadt, Germany, and Pfizer announced a strategic alliance to co-develop and co-commercialize avelumab.
This study estimated the NK cell-mediated cytotoxicity of mice which is treated by MBGS and, furthermore, used the tumor-bearing murine model of inducing the metastasis from the primary tumor by radiation [12] and observes for the effectiveness of MBGS in conjunction with the radiation therapy to control cancer metastasis.
Bottino, “Antibody-dependent cell-mediated cytotoxicity (ADCC) is thought to augment the efficacy of IgG1 mAb therapeutics (eg.
The agent that promotes T cell death can promote AICD (activation induced cell death), passive cell death, ADCC (antibody dependent cell-mediated cytotoxicity) or CDC (complement directed cytotoxicity).
Cell-mediated cytotoxicity in hepatitis A virus infection.
* Enlists immune cells to attack and kill tumour target cells via antibody-dependent cell-mediated cytotoxicity.
Antibody-dependent cell-mediated cytotoxicity (ADCC): A mechanism of cell-mediated immunity whereby certain immune cells actively break up a target cell that has been bound by specific antibodies.
This Globo H targeting antibody has been shown to induce tumour-killing via antibody dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cell-mediated phagocytosis (ADCP) and complement dependent cytotoxicity (CDC).
They also lack CD16 and are thus unable to participate in antibody-dependent cell-mediated cytotoxicity (ADCC).