Combined with pathway analyses, 7 hot genes, except for B2M, participate in the TCR signaling pathway, and LCK, VAV1, IFNG, and TNF participate in the natural killer cell-mediated cytotoxicity
Moreover, recently, in vitro NK cell-mediated cytotoxicity
was enhanced by type I interferon treatment in a model of NK-infected DC coculture , suggesting an important crosstalk between APCs and NK cells for viral clearance.
Avelumab is also thought to help white blood cells such as natural killer (NK) cells find and attack tumors in a process known as ADCC, or antibody-dependent cell-mediated cytotoxicity
. In November 2014, Merck KGaA, Darmstadt, Germany, and Pfizer announced a strategic alliance to co-develop and co-commercialize avelumab.
This study estimated the NK cell-mediated cytotoxicity
of mice which is treated by MBGS and, furthermore, used the tumor-bearing murine model of inducing the metastasis from the primary tumor by radiation  and observes for the effectiveness of MBGS in conjunction with the radiation therapy to control cancer metastasis.
Bottino, “Antibody-dependent cell-mediated cytotoxicity
(ADCC) is thought to augment the efficacy of IgG1 mAb therapeutics (eg.
The agent that promotes T cell death can promote AICD (activation induced cell death), passive cell death, ADCC (antibody dependent cell-mediated cytotoxicity
) or CDC (complement directed cytotoxicity).
in hepatitis A virus infection.
* Enlists immune cells to attack and kill tumour target cells via antibody-dependent cell-mediated cytotoxicity
Antibody-dependent cell-mediated cytotoxicity
(ADCC): A mechanism of cell-mediated immunity whereby certain immune cells actively break up a target cell that has been bound by specific antibodies.
THE INVOLVEMENT OF MAC-1 IN GAMMA DELTA T CELL-MEDIATED CYTOTOXICITY
. Janet L.
This Globo H targeting antibody has been shown to induce tumour-killing via antibody dependent cell-mediated cytotoxicity
(ADCC), antibody-dependent cell-mediated phagocytosis (ADCP) and complement dependent cytotoxicity (CDC).
They also lack CD16 and are thus unable to participate in antibody-dependent cell-mediated cytotoxicity