death pathway

(redirected from cell-death pathway)

death pathway

finding that characterizes a protein that initiates final stage of cell death known as apoptosis. Mammalian families of proteins that execute the apoptotic pathway are Bcl-2, Apaf-1, and caspase-3. FAS receptor-ligand system is a regulator of apoptotic cell death.
Synonym(s): cell-death pathway
References in periodicals archive ?
"Cell-to-cell transmission of HIV is absolutely required for activation of the pathogenic HIV cell-death pathway."
If PKR indeed detects long double-stranded RNA within a cell, the protein triggers a cell-death pathway to eliminate the cell.
Antisense oligonucleotides were shown to be effective in vitro for targeting molecules in the cell-death pathway (e.g., c-Jun) in dissociated cell cultures of the rat spiral ganglion that had been exposed to oxidative stress with cisplatin.
Next the researchers plan to more closely investigate the split in cell-death pathways whereby damage to chromosome ends (telomeres) leads to autophagy while damage to other parts of chromosomes leads to apoptosis.
One distinct role of TNF[alpha] is to induce programmed cell-death pathways (i.e., apoptosis and necroptosis) by binding to and activating death receptors on cells.