"Cell-to-cell transmission of HIV is absolutely required for activation of the pathogenic HIV cell-death pathway
If PKR indeed detects long double-stranded RNA within a cell, the protein triggers a cell-death pathway
to eliminate the cell.
Antisense oligonucleotides were shown to be effective in vitro for targeting molecules in the cell-death pathway
(e.g., c-Jun) in dissociated cell cultures of the rat spiral ganglion that had been exposed to oxidative stress with cisplatin.
Next the researchers plan to more closely investigate the split in cell-death pathways
whereby damage to chromosome ends (telomeres) leads to autophagy while damage to other parts of chromosomes leads to apoptosis.
One distinct role of TNF[alpha] is to induce programmed cell-death pathways
(i.e., apoptosis and necroptosis) by binding to and activating death receptors on cells.