death pathway

(redirected from cell-death pathway)

death pathway

finding that characterizes a protein that initiates final stage of cell death known as apoptosis. Mammalian families of proteins that execute the apoptotic pathway are Bcl-2, Apaf-1, and caspase-3. FAS receptor-ligand system is a regulator of apoptotic cell death.

Synonym(s): cell-death pathway

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References in periodicals archive ?

"Cell-to-cell transmission of HIV is absolutely required for activation of the pathogenic HIV cell-death pathway."

Study: HIV does not cause AIDS, human immune cells do

If PKR indeed detects long double-stranded RNA within a cell, the protein triggers a cell-death pathway to eliminate the cell.

New process to 'program' cancer cell death created

Antisense oligonucleotides were shown to be effective in vitro for targeting molecules in the cell-death pathway (e.g., c-Jun) in dissociated cell cultures of the rat spiral ganglion that had been exposed to oxidative stress with cisplatin.

Pharmacologic manipulation of the labyrinth with novel and traditional agents delivered to the inner ear. (Original Article)

Next the researchers plan to more closely investigate the split in cell-death pathways whereby damage to chromosome ends (telomeres) leads to autophagy while damage to other parts of chromosomes leads to apoptosis.

Cellular Process Can Ward Off Cancer

One distinct role of TNF[alpha] is to induce programmed cell-death pathways (i.e., apoptosis and necroptosis) by binding to and activating death receptors on cells.