cell transformation


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cell trans·for·ma·tion

morphologic and physiologic changes including loss of contact inhibition resulting from infection of an animal cell by an oncogenic virus.
References in periodicals archive ?
carcinogens will be analysed in this assay along with the potential of CRISPR/Cas9 editing to induce cell transformation
At the same time, there were significant morphological differences found after cell transformation when the cells were observed by Giemsa staining.
Kim et al., "Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival," British Journal of Cancer, vol.
Martin et al., "Spontaneous human adult stem cell transformation," Cancer Research, vol.
Hanawalt, "DNA damage stimulates human cell transformation by integrative but not episomal Epstein-Barr virus-derived plasmid," Molecular Carcinogenesis, vol.
Although the steroid hormones profile was not assessed in the study, we suggest that the prolonged effect of E2 treatment may act via different mechanisms during GC-luteal cell transformation and/or significantly alter this process in vitro.
Large cell transformation was suspected, but the specimen showed a diffuse mixed cell pattern.
The separate pathological effects of high-risk HPV E6 and E7 on the cell cycle complement each other, and together E6 and E7 mediate the HPV-associated epithelial cell transformation and promote cellular genomic instability that predisposes the infected cells to full malignant transformation.
Warnes, "Endothelial cell transformation in primary biliary cirrhosis: a morphological and biochemical study," Hepatology, vol.
(1) The prognostic factors of MF include the type and extent of skin involvement, (2-4) the presence of extracutaneous disease, (2) advanced age, (4) male sex, (4) folliculotropic variant, (2,4) elevated lactate dehydrogenase (LDH), (4) and large cell transformation. (4,5) In a large cohort of transformed MF patients, the extent of skin involvement and extracutaneous transformation were associated with worse disease-specific survival and overall survival.
The topics include the use of human embryonic stem cells in high-throughput toxicity assays, high-throughput screening assays to assess chemical phototoxicity, an automated soft agar colony formation assay for the high-throughput screening of malignant cell transformation, single-cell imaging cytometry-based high-throughput analysis of drug-induced cardiotoxicity, and evaluating the peroxisomal phenotype in high content toxicity profiling.
The revolutionary biotechnology discoveries of these three individuals--each working in separate facilities on two continents--unlocked the key to plant cell transformation using recombinant DNA.