Cells were stained for mesenchymal cell surface marker
antibodies, CD90, CD44 and CD73.
This new program will focus on an undisclosed, first-in-class monoclonal antibody targeting a specific cell surface marker
implicated in an auto-immune ultra-orphan disease that primarily affects children.
Results of RT-PCR to evaluate growth factor and cell surface marker
mRNA expression of ADSCs (Supplemental Figure 1A).
This may be related to the limitation of the cell surface marker
used, EpCAM, since it may be lost during disease progression or depending on the state of the cells.
Moreover, CD44 is the most prevalent cell surface marker
of cancer stem cells.
Other strategies being pursued include reprogramming of cancer stem cells and the targeting of a functional cell surface marker
in liver cancer stem cells, the aminopeptidase CD13.
Table 2: Cell surface marker
phenotyping of immune cells between CS and controls.
Cell surface marker
expression, fluorescent dye (Hoechst 33342) exclusion in the side population and tumor sphere formation in the suspension culture are strategies that have been performed to identify Breast Cancer Stem Cells (Al-Hajj et al, 2003).
Najm, "Expression of neural stem cell surface marker
CD133 in balloon cells of human focal cortical dysplasia," Epilepsia, vol.
In vitro assays, such as the efflux-based SP assay, ALDH activity assay, and cell surface marker
assays, have proven to be reproducible and straightforward methods of CSC detection.
Multiple myeloma cell lines and primary patient derived cells express the cell surface marker
Efalizumab is a recombinant humanized monoclonal antibody that binds to lymphocyte cell surface marker
CD11a, inhibiting the "activation and trafficking of T cells," according to Genentech Inc., which is developing efalizumab in collaboration with the biotech company Xoma.