CD44

(redirected from cell surface glycoprotein CD44)

CD44

a type I transmembrane protein present on T cells, pre-B cells, monocytes, neutrophils, CNS white matter, fibroblasts, skeletal muscle, and medullary thymocytes; facilitates lymphocyte binding to endothelial venules and assists in adhesion.

CD44

A gene on chromosome 11q13 that encodes a cell surface glycoprotein involved in cell–cell interactions, cell adhesion and cell migration, and which is a receptor for hyaluronic acid. CD44 also interacts with other ligands—e.g., osteopontin, collagens and matrix metalloproteinases—and participates in a range of cellular functions including lymphocyte activation, recirculation and homing, haematopoiesis and tumour metastasis.
References in periodicals archive ?
Ostermann et al., "Splice variants of the cell surface glycoprotein CD44 associated with metastatic tumour cells are expressed in normal tissues of humans and cynomolgus monkeys," European Journal of Cancer, vol.