RAD17

(redirected from cell cycle checkpoint protein)

RAD17

A gene on chromosome 5q13 which encodes a protein that binds to chromatin before DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. RAD17 recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage. RAD17 phosphorylation is required for the DNA-damage-induced cell cycle G2 arrest, and is a critical early event during checkpoint signalling in DNA-damaged cells.
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cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proceedings of National Academy of Sciences, 93: 2850-2855.
Kaufmann and colleagues found that the human Timeless protein interacted with both Cry2 (a confirmed circadian clock protein) and Chk1 kinase (a cell cycle checkpoint protein).

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