Cell cycle checkpoint protein | definition of cell cycle checkpoint protein by Medical dictionary
RAD17 (redirected from cell cycle checkpoint protein)
RAD17 A gene on chromosome 5q13 which encodes a protein that binds to chromatin before DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. RAD17 recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage. RAD17 phosphorylation is required for the DNA-damage-induced cell cycle G2 arrest, and is a critical early event during checkpoint signalling in DNA-damaged cells.
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References in periodicals archive
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein
. Proceedings of National Academy of Sciences, 93: 2850-2855.
Kaufmann and colleagues found that the human Timeless protein interacted with both Cry2 (a confirmed circadian clock protein) and Chk1 kinase (a cell cycle checkpoint protein
Honokiol affects cell cycle checkpoint proteins
in glioma cells.