Acer's pipeline includes three clinical-stage candidates: EDSIVO (celiprolol
) for the treatment of vascular Ehlers-Danlos syndrome (vEDS) in patients with a confirmed type III collagen (COL3A1) mutation; ACER-001 (a fully taste-masked, immediate release formulation of sodium phenylbutyrate) for the treatment of various inborn errors of metabolism, including urea cycle disorders (UCDs) and Maple Syrup Urine Disease (MSUD) and osanetant for the treatment of induced Vasomotor Symptoms (iVMS) where Hormone Replacement Therapy (HRT) is likely contraindicated.
Also, in April 2019, we announced the publication of the Paris registry data in JACC that supplements the previously-reported safety and efficacy of celiprolol
in vEDS patients with a confirmed type III collagen mutation."
A 25-year-old primigravida female presented to the emergency room with amenorrhoea since 10 weeks and vaginal bleeding since 6 hours.The patient had Graves' disease without symptoms of hoarseness or dysphagia, and consuming carbimazole and celiprolol
. There was nothing remarkable in her medical history.
(4) Beta-blocker therapy, specifically with celiprolol
, has been shown to reduce the overall frequency of arterial ruptures and dissections and should be considered in all cases.
Matsumoto et al., "Effects of the antioxidative [beta]-blocker celiprolol
on endothelial progenitor cells in hypertensive rats," American Journal of Hypertension, vol.
The 2nd generation agents or the cardioselective agents (such as atenolol, bisoprolol, celiprolol
, and metoprolol) block [beta]1-receptors in low doses but are capable of blocking [beta]2-receptors in higher doses.
Cardiosseletivos Nao seletivos Drogas com atividade al antagonista adicional Acebutolol * Alprenolol * Bucindolol Atenolol Carteolol * Carvedilol Betaxolol Nadolol Labetalol Bevantolol Oxprenolol * Bisoprolol Penbutolol * Celiprolol
Pindolol * Esmolol Propranolol Metoprolol Sotalol Practolol * Timolol Quadro 4: Criterios usados na selecao e forma de obtencao dos dados.
Proceeds from the funding round will primarily be used to prepare a new drug application (NDA) for ACER-002 (celiprolol
hydrochloride), Acer's lead candidate which is being developed for the treatment of vascular Ehlers-Danlos Syndrome (vEDS), a rare, life-threatening genetic connective tissue disorder.
Nomura et al., "Celiprolol
reduces oxidative stress and attenuates left ventricular remodeling induced by hypoxic stress in mice," Hypertension Research, vol.
Beta Blockers acebutolol, alprenolol, atenolol, betaxolol, bisoprolol, bunolol, carteolol, carvedilol, celiprolol
, esmolol, labetalol, levobunolol, metipranolol, metoprolol, nadolol, oxprenolol, pindolol, propranolol, sotalol, timolol
Mechanisms of combined treatment with celiprolol
and candesartan for ventricular remodeling in experimental heart failure.