cefuroxime


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Related to cefuroxime: Cefuroxime axetil, Cefixime

cefuroxime

 [sef″u-rok´sēm]
a semisynthetic, β-lactamase–resistant, second-generation cephalosporinantibiotic effective against a wide range of gram-positive and gram-negative bacteria; used as the sodium salt and the axetil ester.

cefuroxime

/cef·u·rox·ime/ (sef″u-rok´sēm) a semisynthetic, β–resistant, second-generation cephalosporin effective against a wide range of gram-positive and gram-negative bacteria; used as the sodium salt and the axetil ester.

cefuroxime

(sĕf′yə-rŏk′sēm′)
n.
A broad-spectrum cephalosporin antibiotic given orally and parenterally for respiratory, skin, and other infections.

cefuroxime

A second-generation CEPHALOSPORIN antibiotic active against staphylococci and some Gram-negative organisms. It must be given by injection. Brand names are Zinacef and Zinnat.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.

cefuroxime

a second generation cephalosporin antibiotic.
References in periodicals archive ?
4% (175/226) for those who received 10 days of treatment with either amoxicillin-clavulanate or cefuroxime axetil.
TMP-SMX and amoxicillin had the highest resistance rate (68%, N=25 and 65%, N=24, respectively), followed by cefuroxime and ciprofloxacin at 41% (N=15) each and co-amoxiclav at 27% (N=10) (Fig.
Of interest was the clinical failure of cefuroxime therapy, despite the isolate's in vitro susceptibility, and the rapid response to ciprofloxacin treatment.
Of these patients, 169 were randomized to 320 mg oral gemifloxacin once daily for 7-14 days, while 172 received 2 g intravenous ceftriaxone for 1-7 days, followed by 500 mg oral cefuroxime twice daily for 1-13 days for a total of no more than 14 days.
Among the [beta]-lactams agents, cefuroxime had the highest level of resistance across the southern regions followed by penicillin (at MIC [greater than or equal to] 2 mg/L) and amoxicillin-clavulanate (Table 1).
The second choice is amoxicillin, the third is cefpodoxime proxetil, and the fourth is cefuroxime axetil.
Braun will expand its broad spectrum of intravenous cephalosporin antibiotic therapies for the hospital setting: Cefepime, Ceftazidime, Cefoxitin, CefTRIaxONE, Cefazolin, CefUROXime and Cefotetan.
If [beta]-lactam resistant pneumococcus is suspected, ceftriaxone [Rocephin] may be a reliable choice, while the cephalosporin cefuroxime [Ceftin] may be associated with increased mortality if used in the presence of in vitro resistance to this agent," he said.
Three days later, he became febrile, and pyrexia persisted despite local wound management and treatment with oxacillin, 4 g/day for 3 days; cefuroxime, 3 g/day, and gentamicin, 160 mg/day for another 7 days.
The patient's postoperative course was unremarkable, and he was discharged home on postoperative day 2 and prescribed 6 weeks of intravenous cefuroxime.