ceftriaxone


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Related to ceftriaxone: Azithromycin

ceftriaxone

 [sef″tri-ak´sōn]
a semisynthetic, β-lactamase–resistant, third-generation cephalosporin effective against a wide range of gram-positive and gram-negative bacteria, used as the sodium salt.

ceftriaxone

(sĕf′trī-ăk′sōn′)
n.
A broad-spectrum cephalosporin antibiotic, C18H18N8O7S3, that is given intravenously in the form of its sodium salt and used commonly to treat gonorrhea.

ceftriaxone

Rocephin® Infectious disease An advanced generation cephalosporin used for RTIs, UTIs, skin infections, PID, gonorrhea, septicemia, intra-abdominal infections, meningitis, neurosyphilis, surgical prophylaxis Side effects Diarrhea, liver dysfunction

ceftriaxone

A CEPHALOSPORIN ANTIBIOTIC drug. The drug is on the WHO official list. The drug is on the WHO official list. A brand name is Rocephin.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.
References in periodicals archive ?
E-test strip of penicillin (Oxoid) and ceftriaxone (Biomerieux) were placed over the lawn on two separate 90mm SB-MHA plates incubated in 5% carbon di-oxide (CO2) enriched atmosphere for 24h.
The mean age of subjects of azithromycin receiving group was 7.3 years & that for ceftriaxone receiving group was 8.6 years.
Gonococcal strains with mosaic penA--10.001 also can cause ceftriaxone treatment failure (17).
The effect of ceftriaxone on plasma, erythrocyte and tissue TBARS levels in mice are presented in Table 1.
That suggests zoliflodacin was not as effective as ceftriaxone in treating pharyngeal gonorrhea, which is generally considered more difficult to treat than infections at other sites, according to the authors.
A total of 47 subjects received the 3-g ETC0914 dose, while 49 subjects received the 2-g dose, and the rest received ceftriaxone. All patients (47/47) receiving the 3-g dose were cured, and 98 percent (48/49) in the 2 -g dose were cured, with only 21 subjects (12 percent) in the entire study population reporting mild side effects.
Miro et al., "Brief communication: treatment of Enterococcus faecalis endocarditis with ampicillin plus ceftriaxone," Annals of Internal Medicine, vol.
In this study, most of the Enterobacteriaceae (Citrobacter koseri, Enterobacter cloacae, Klebsiella oxytoca, Enterobacter aerogenes, and Proteus species) isolates were resistant to ceftriaxone or ceftazidime.
(16) In settings where there is a high frequency of testing (an average of 17 tests per day), with a presumed ciprofloxacin resistance rate approaching 25 percent (the national estimate (17)), as well as a 30 percent rate of infections with indeterminate genotype results, the cost of gyrA genotyping with genotype-based targeted therapy was only $12.41 more expensive per case than recommended two-drug ceftriaxone and azithromycin therapy.
The literature describes some methods for the analysis of ceftriaxone sodium such as bioassay [9], HPLC [10-14], fluorimetry [15, 16], titrimetry [17], spectrophotometry [18-22], and micellar electrokinetic capillary chromatography [23-25].