ceftibuten


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ceftibuten

 [sef-ti´bu-ten]
a third-generation cephalosporin antibiotic used in treatment of bronchitis, pharyngitis, tonsillitis, and acute otitis media; administered orally.

ceftibuten

Cedax

Pharmacologic class: Third-generation cephalosporin

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Interferes with bacterial cell-wall synthesis and division by binding to cell wall, causing cell to die. Active against gram-negative and gram-positive bacteria, with expanded activity against gram-negative bacteria. Exhibits minimal immunosuppressant activity.

Availability

Capsules: 400 mg

Oral suspension: 90 mg/5 ml

Indications and dosages

Acute bacterial exacerbations of chronic bronchitis caused by Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae; pharyngitis and tonsillitis caused by Streptococcus pyogenes; acute bacterial otitis media caused by H. influenzae, M. catarrhalis, and S. pyogenes
Adults and children ages 12 and older: 400 mg P.O. q 24 hours for 10 days
Children ages 12 and younger: 9 mg/kg P.O. daily for 10 days. Maximum dosage shouldn't exceed 400 mg daily.

Dosage adjustment

• Renal impairment

Off-label uses

• Urinary tract infections

Contraindications

• Hypersensitivity to cephalosporins and penicillins

Precautions

Use cautiously in:
• renal impairment, hepatic disease, biliary obstruction, phenylketonuria
• history of GI disease
• elderly patients
• pregnant or breastfeeding patients
• children.

Administration

• Obtain specimens for culture and sensitivity testing as necessary before starting therapy.
• Give oral suspension at least 1 hour before or 2 hours after a meal.

Adverse reactions

CNS: headache, lethargy, paresthesia, syncope, seizures

CV: hypotension, palpitations, chest pain, vasodilation

EENT: hearing loss

GI: nausea, vomiting, diarrhea, abdominal cramps, oral candidiasis, pseudomembranous colitis

GU: vaginal candidiasis, nephrotoxicity

Hematologic: lymphocytosis, eosinophilia, bleeding tendency, hemolytic anemia, hypoprothrombinemia, neutropenia, thrombocytopenia, agranulocytosis, bone marrow depression

Hepatic: hepatic failure, hepatomegaly

Musculoskeletal: arthralgia

Respiratory: dyspnea

Skin: urticaria, easy bruising, maculopapular or erythematous rash

Other: chills, fever, superinfection, anaphylaxis, serum sickness

Interactions

Drug-drug.Aminoglycosides, loop diuretics: increased risk of nephrotoxicity

Probenecid: decreased excretion and increased blood level of ceftibuten

Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, eosinophils, gamma-glutamyltransferase, lactate dehydrogenase: increased levels
Coombs' test, urinary 17-ketosteroids, nonenzyme-based urine glucose tests (such as Clinitest): false-positive results

Hemoglobin, platelets, white blood cells: decreased values

Drug-herbs.Angelica, anise, arnica, asafetida, bogbean, boldo, celery, chamomile, clove, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, horse chestnut, horseradish, licorice, meadowsweet, onion, papain, passionflower, poplar, prickly ash, quassia, red clover, turmeric, wild carrot, wild lettuce, willow: increased risk of bleeding

Patient monitoring

• Assess CBC and kidney and liver function test results.
• Monitor for signs and symptoms of superinfection and other serious adverse reactions.
• Be aware that cross-sensitivity to penicillins may occur.

Patient teaching

• Instruct patient to take oral suspension at least 1 hour before or 2 hours after a meal.
• Inform diabetic patient that oral suspension contains 1 g sucrose per teaspoon.
• Advise patient to continue to take full amount prescribed even when he feels better.
• Tell patient to report signs and symptoms of allergic response and other adverse reactions, such as rash, easy bruising, bleeding, severe GI problems, or difficulty breathing.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and herbs mentioned above.

ceftibuten

/cef·ti·bu·ten/ (sef-ti´bu-ten) a third-generation cephalosporin used in treatment of bronchitis, pharyngitis, tonsillitis, and otitis media.

ceftibuten

(sĕf-tī′byo͞o-tn)
n.
A broad-spectrum cephalosporin antibiotic, C15H14N4O6S2, used primarily to treat ear and respiratory infections.

ceftibuten

an oral third-generation cephalosporin.
indications It is prescribed in the treatment of chronic bronchitis, acute bacterial otitis media, pharyngitis, and tonsillitis.
contraindications It should not be given to children with abdominal pain, vomiting, and diarrhea.
adverse effects The side effects most often reported include nausea, headache, diarrhea, dyspepsia, dizziness, and abdominal pain.

ceftibuten

Cedax® A once-daily broad-spectrum cephalosporin used for acute bacterial otitis media, acute bacterial exacerbation of chronic bronchitis, pharyngitis/tonsillitis. See Cephalosporin.

ceftibuten (sef´tib´yōōtən),

n brand name: Cedax;
drug class: third-generation cephalosporin;
action: causes cell death by attaching to the bacterial membrane wall;
uses: lower respiratory and urinary tract infections, gynecologic and enteric infections, pharyngitis, tonsillitis, and otitis media caused by susceptible organisms.
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References in periodicals archive ?
Although no NCCLS-approved breakpoints have been developed for cefaclor, loracarbef, and ceftibuten versus S.
After the initial 2 weeks, 8 patients on ceftibuten and 14 on amoxicillin or trimethoprim-sulfamethoxazole (TMP-SMX) had adverse events associated with sinusitis, an insignificant difference between groups, said Dr.
Five patients in the ceftibuten group and six in the amoxicillin or TMP-SMX group required a second antibiotic after a suboptimal clinical response in the initial 2 weeks, he said at the annual meeting of the American Academy of Allergy, Asthma, and Immunology.