cefotaxime


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cefotaxime

 [sef´o-tak″sēm]
a third-generation cephalosporinantibiotic having a broad spectrum of activity, including against penicillinase-producing bacterial strains.

cefotaxime

(sĕf′ō-tăk′sēm′)
n.
A broad-spectrum cephalosporin antibiotic, C16H17N5O7S2, given intravenously in the form of its sodium salt.

cefotaxime

A third-generation CEPHALOSPORIN antibiotic active against Gram-negative organisms but not staphylococci. A brand name is Claforan.
References in periodicals archive ?
A total of 150 gynaecological surgeries were taken for the study, such that 75 patients were given cefazolin prophylaxis & the next 75 patients were given cefotaxime & metronidazole.
coli isolates showed more sensitivity to Amikacin 57(76%) followed by Imipenem 57(66.67%), Ofloxacin 48(64%), Ciprofloxacin 44(58.67%), Norfloxacin 42(56%) and 75(100%) were resistant to Penicillin, Ceftriaxone, Ceftazidime and Cefotaxime (Table-2 and Figure-2).
As no endovascular source was confirmed, it was decided that the patient would complete a 2-week course with ampicillin and cefotaxime from the date of first negative culture.
The sludge samples (1 mL) were inoculated in 2 mL of Brain Heart Infusion (BHI) broth which contained cefotaxime (2 mg/L) and then the sample was incubated at 37AdegC for two hours under aerobic conditions.
The highest rooting frequency (100.00%) was observed on MS medium supplemented with 0.2 mg L-1 indole acetic acid (IAA) and 400 mg L-1 cefotaxime. The rooting frequencies observed on MS medium, supplemented with 0.2 mg L-1 a-naphthaleneacetic acid (NAA) and 400 mg L-1 cefotaxime, and on 1/2 MS medium, supplemented with 0.2 mg L-1 IAA and 400 mg L-1 cefotaxime, were 89.5% and 83.13%, respectively.
Phenotypic confirmatory test of provisional ESBLs producers was carried out by combined disk method by using antimicrobial disks of Ceftazidime (30g) and Cefotaxime (30g) alone and in combination with Cla-vulanic acid (30/10g) on Mueller Hinton agar plates.
(Table 5) was found to be maximum sensitive for Ciprofloxacin (100%) followed by Norfloxacin (100%), Ceftriaxone (100%), Cefotaxime (100%) and Tobramycin (50%) while resistant to Chloramphenicol, Gentamicin, Amikacin, Kanamycin, Neomycin, Enrofloxacin, Cephalexin, Clindamycin and Streptomycin.
aureus, cloxacillin (96.77%), cefotaxime (91.94%), and ciprofloxacin (77.42%) were found to be the most effective drugs with the least resistance.
The rates of cefotaxime resistance in Salmonella Virchow have increased markedly, from 21.4% in 2011 to 82.3% in 2014.
aeruginosa isolates were found to be sensitive to ceftazidime which is also supported by another study.18 On the other hand only 37% of isolates showed sensitivity to cefotaxime in our study; meaning that in our set up, ceftazidim is effective but resistance against cefotaxime has increased in the recent past.
Cefotaxime sodium salt was purchased from Pharmaceutical Laboratory of Cuba (IMEFA).
Conclusion: Single dose antibiotic (cefotaxime) is as effective as multiple doses of antibiotics (cefotaxime) in the prophylaxis of postoperative wound infection in elective caesarian section.