After surgery, cefmetazole was prescribed on May 6 (1 g 2x/d for 7 d).
org), were as follows: sulbactam/ampicillin, >128 mg/L; piperacillin, >128 mg/L; tazobactam/piperacillin, >128 mg/L; cefotaxime, >64 mg/L; ceftazidime, >64 mg/L; aztreonam, 64 mg/L; cefmetazole, >128 mg/L; imipenem, 8 mg/L; meropenem, 32 mg/L; and doripenem, 32 mg/L.
With the use of cefmetazole
as a probe drug, the excretory profile of chimeric mice was shown to be similar to that of humans (16), a finding that suggests that chimeric mice may be a useful animal model in excretion studies.
uva-ursi Baicalin [beta]-Lactam antibiotics MRSA Tellimagrandin I [beta]-Lactams MRSA from rose red tree, Rugosin B from [beta]-Lactams MRSA rose red tree Diterpenes from Tetracycline S.
Even though the cephamycin antibiotics--cefotetan, cefmetazole
, and cefoxitin--may appear to test susceptible, their usefulness in treating serious infections with ES[beta]L producers is unclear.
On the first day of her admission, the administration of cefmetazole
(750 mg/day) and fosfomycin (750 mg/day) were begun.
After the operation, the patient was treated with cefmetazole
MICs of 14 antimicrobial drugs (penicillin, piperacillin/ tazobactam, ampicillin/sulbactam, cefmetazole
, meropenem, imipenem, doripenem, ertapenem, metronidazole, vancomycin, teicoplanin, fusidic acid, clindamycin, and daptomycin) were determined by the agar dilution method described by the Clinical and Laboratory Standards Institute (22).
A routine perioperative intravenous antimicrobial agent, cefmetazole
, was administered as surgical prophylaxis.
It has intermediate susceptibility to ciprofloxacin, doxycycline, and tobramycin; variable susceptibility to cefmetazole
, cefoxitin, and clarithromycin; and resistance to isoniazid and rifampin (1).
Both GS553 and GS554 strains, which produced cephalosporinase as well as penicillinase, were resistant to cefotetan, cefmetazole
, and cefoxitin as well as piperacillin, cefotaxime, ceftriax-one, cefpodoxime, cefepime, and aztreonam.
The patient was treated with cefmetazole
sodium (2 g per day for 3 weeks) and piperacillin sodium (2 g per day for 2 weeks) after surgical soft tissue debridement.