cefepime


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cefepime

 [sef´ĕpēm]
a semisynthetic fourth-generation cephalosporinantibiotic; used in the treatment of infections of the skin and soft tissues and of the respiratory and urinary tracts. Administered intravenously or intramuscularly as the hydrochloride salt.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cefepime

(sĕf′ə-pēm′)
n.
A broad-spectrum cephalosporin antibiotic, C19H24N6O5S2, used in its hydrochloride form to treat a variety of infections, including skin and urinary tract infections and certain types of pneumonia.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

cefepime

Maxipime® Infectious disease A 4th-generation cephalosporin Indications RTIs–eg bronchitis, pneumonia; cellulitis and other skin and soft-tissue infections; UTIs–eg pyelonephritis, febrile neutropenia, PID, gonorrhea, septicemia, intra-abdominal infections, meningitis, surgical prophylaxis. See Cephalosporin.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Presentation title: The Exposure?Response Relationship of Enmetazobactam, Combined with Cefepime, Is Best Described by fT - CT in a Murine Thigh Infection Model
Preclinical results showed that cefepime/VNRX-5133 showed potent in vitro activity against all Enterobacteriaceae, with an MIC90 of 0.5 mg/L, compared to cefepime, levofloxacin, meropenem, and piperacillin-tazobactam (MIC90 values >128, >4, 4, >64 mg/L, respectively).
Similarly the Study of Tapan Majumdar, Shibabrata Bhattacharya et al, it was obtained that overall antibiotic resistant pattern of the isolates showed a high degree of resistance towards Amoxycillin, 3rd generation Cephalosporins and Tetracycline whereas Cefepime, Imipenem Amino Glycosides were showing less resistance.
La figura 1 muestra los diferentes esquemas de tratamiento prescriptos: el 16 % de los pacientes utilizo imipenem/cilastatina 500/500 mg y con el mismo porcentaje la ampicilina/sulbactam 1000/500 mg asociada con claritromicina 500 mg; en menor cantidad, se utilizo la ceftriaxona 1000 mg y la combinacion de cefepime 1000 mg con amikacina 500 mg, ambas con el mismo porcentaje (4 %).
This patient improved after intravenous therapy with cefepime and metronidazole.
Serious adverse events occurred in 12% of the combination group and 7% of the cefepime group.
No resistance was noted for doripenem and cefepime. MIC50 was 0.094 for Cefpirome, 0.125 Aztreonam, 0.25 imipenem and tigecycline, 2 cefpodoxime and 8 for azithromycin.
As for antibiotic treatment, cefepime (a fourthgeneration cephalosporin) is often employed as a first-line therapy for agranulocytosis with infection.
The following antibiotic discs were tested: ceftazidime (30 [micro]g), cefepime (30 [micro]g), piperacillin-tazobactam (100 [micro]g/10 [micro]g), Imipenem (10 [micro]g), Meropenem (10 [micro]g), Gentamicin (10 [micro]g), Amikacin (30 [micro]g), Ampicillin-sulbactam (10 [micro]g/10 [micro]g), Cotrimoxazole (25 [micro]g), aztreonam (30 [micro]g), Ciprofloxacin (5 [micro]g), Norfloxacin (30 [micro]g) (for urinary isolates), Polymyxin B (300 units), and Colistin (10 [micro]g).
Though prospective research demonstrating effectiveness of other therapies has been limited, there is emerging retrospective evidence in support of the use of cefepime, fluoroquinolones, and piperacillin/tazobactam in certain clinical situations [5-10].
The patient was started empirically on cefepime, doxycycline, and vancomycin to ensure adequate coverage of suspected marine pathogens.
The different anti-microbials tested were piperacillin (100 ug), ceftazidime (30 ug), amikacin (30 ug), piperacillin-tazobactam (100/10 ug), imipenem (10 ug), ciprofloxacin (5 ug), cefepime (30 ug), ceftriaxone (30 ug), aztreonam (30 ug) and cefoperazone (30 ug).