cefadroxil


Also found in: Dictionary, Thesaurus, Wikipedia.
Related to cefadroxil: Cefixime

cefadroxil

 [sef″ah-drok´sil]
a semisynthetic first-generation cephalosporinantibiotic effective against a wide range of gram-positive and a very limited number of gram-negative bacteria.

cefadroxil

Baxan (UK), Novo-Cefadroxil (CA)

Pharmacologic class: First-generation cephalosporin

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Interferes with bacterial cell-wall synthesis, causing cell to rupture and die

Availability

Capsules: 500 mg

Oral suspension: 250 mg/5 ml, 500 mg/5 ml

Tablets: 1 g

Indications and dosages

Pharyngitis and tonsillitis caused by beta-hemolytic streptococci

Adults: 1 g/day P.O. or 500 mg P.O. b.i.d. for 10 days

Children: 30 mg/kg/day P.O. in divided doses q 12 hours for 10 days

Skin infections caused by staphylococci and streptococci

Adults: 1 g/day P.O. or 500 mg P.O. q 12 hours

Children: 30 mg/kg/day P.O. in divided doses q 12 hours

Urinary tract infections caused by Proteus mirabilis, Escherichia coli, and Klebsiella species

Adults: 1 to 2 g/day P.O. in divided doses q 12 hours

Children: 30 mg/kg/day P.O. in divided doses q 12 hours

Dosage adjustment

• Renal insufficiency

• Elderly patients

Off-label uses

• Bone and joint infections

• Unspecified respiratory infections

Contraindications

• Hypersensitivity to cephalosporins or penicillins

Precautions

Use cautiously in:

• renal impairment, phenylketonuria

• history of GI disease (especially colitis)

• elderly patients

• pregnant or breastfeeding patients

• children.

Administration

• Obtain specimens for culture and sensitivity testing as necessary before starting therapy.

• Give with or without food.

Adverse reactions

CNS: headache, lethargy, paresthesia, syncope, seizures

CV: hypotension, palpitations, chest pain, vasodilation

EENT: hearing loss

GI: nausea, vomiting, diarrhea, cramps, oral candidiasis, pseudomembranous colitis

GU: vaginal candidiasis, nephrotoxicity

Hematologic: lymphocytosis, eosinophilia, bleeding tendency, hemolytic anemia, hypoprothrombinemia, neutropenia, thrombocytopenia, agranulocytosis, bone marrow depression

Hepatic: hepatic failure, hepatomegaly

Musculoskeletal: arthralgia

Respiratory: dyspnea

Skin: urticaria, maculopapular or erythematous rash

Other: chills, fever, superinfection, anaphylaxis

Interactions

Drug-drug. Aminoglycosides, loop diuretics: increased risk of nephrotoxicity

Probenecid: decreased excretion and increased blood level of cefadroxil

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, eosinophils, gamma-glutamyltransferase, lactate dehydrogenase: increased levels
Coombs' test, urinary 17-ketosteroids, nonenzyme-based urine glucose tests (such as Clinitest): false-positive results

Hemoglobin, platelets, white blood cells: decreased values

Patient monitoring

• Assess baseline CBC and kidney and liver function test results.

• Monitor for signs and symptoms of superinfection and other serious adverse reactions.

• Be aware that cross-sensitivity to penicillins may occur.

• With long-term therapy, obtain monthly Coombs' test.

Patient teaching

• Advise patient to take drug with food or milk if GI upset occurs.

• Instruct patient to complete entire course of therapy even if he feels better.

• Tell patient to report signs and symptoms of allergic response and other adverse reactions, such as rash, easy bruising, bleeding, severe GI problems, wheezing, or difficulty breathing.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

cefadroxil

(sĕf′ə-drŏk′səl)
n.
A broad-spectrum cephalosporin antibiotic, C16H17N3O5S, that is given orally.

cefadroxil

A CEPHALOSPORIN ANTIBIOTIC drug. A brand name is Baxan
References in periodicals archive ?
Draft Guidance on Cefadroxil; CefadroxilHemihydrate.
A pharmacokinetic comparison of Cefadroxil and cephalexin after administration of 250, 500 and 1000 mg solution doses.
Pharmacokinetics of Cefadroxil after oral administration in humans.
Relevance ofPepTl in the intestinal permeability and oral absorption of Cefadroxil. Pharm Res.
Subsequent reports, which attributed up to 10% cross-reactivity between the 2 drug classes, involved these same first-generation cephalosporins plus cephalexin and cefadroxil and a second-generation drug, cefamandole.
When patients with a positive history of penicillin-allergy received first-generation cephalosporins, which share a chemical side chain similar to penicillin or amoxicillin (cephalothin, cephaloridine, cephalexin, cefadroxil, and cefazolin, plus the early second-generation cephalosporin, cefamandole), they exhibited a significant increased risk of an allergic reaction to the cephalosporin.
(26) In another study of clinical cross-reactivity between amoxicillin and cefadroxil in patients allergic to amoxicillin with good tolerance of penicillin, only 12% had an immediate allergic reaction to cefadroxil, despite the 2 drugs sharing an identical side chain.
Penicillin-allergic patients have indeed shown an increased incidence of allergic reactions to cephalothin, cephaloridine, cephalexin, cefadroxil, cefazolin, and cefamandole.
Tender notice number : E-656/HBPCL/PC/ Cefadroxil 1gm Tab/2017-18 ID:2018_HBPCL_305112_2
for the active substance cefadroxil, The aok rheinland-pfalz / saarland - die gesundheitskasse offers discount agreements to all interested pharmaceutical companies for the period up to the entry into force of exclusive contracts following a formal award procedure in accordance with the provisions of part 4 of the gwb.