CAV2

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CAV2

A gene on chromosome 7q31.1 that encodes caveolin 2, the main scaffolding protein of the inner surface of caveolae (small invaginations of plasma membranes). Caveolin 2 is involved in essential cellular functions, including signal transduction, lipid metabolism, control of cell growth and apoptosis; it may function as a tumour suppressor.
References in periodicals archive ?
de Almeida, "Caveolin-1 and caveolin-2 can be antagonistic partners in inflammation and beyond," Frontiers in immunology, vol.
The caveolin family consists of 3 members, caveolin-1, caveolin-2, and caveolin-3.
Sitia, "Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors," Genomics, vol.
Yoshino et al., "MicroRNA-218 inhibits cell migration and invasion in renal cell carcinoma through targeting caveolin-2 involved in focal adhesion pathway," Journal of Urology, vol.
Caveolin-2 is most prominently expressed in fibrous and adipose tissue and caveolin-3 is restricted to striated and smooth muscle.
So far, 3 members of the caveolin family have been found in mammals: caveolin-1, caveolin-2 and caveolin-3.
Yang, "MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2," Journal of Cell Science, vol.
Caveolin-1 is a 21-kDa integral membrane protein and one of the major structural components of caveolae in most mammalian cells, along with caveolin-2 and caveolin-3.