CAV1

(redirected from caveolin-1)

CAV1

A gene on chromosome 7q31.1 that encodes caveolin 1, the main scaffolding protein of caveolae plasma membranes in most cells. Caveloin 1 links integrin subunits to the tyrosine kinase FYN, an early step in coupling integrins to the Ras-ERK pathway which drives cell cycle progression; CAV1 is a tumour suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and form a stable hetero-oligomeric complex with other colocalising proteins.

Molecular pathology
CAV1 mutations are linked to congenital generalised lipodystrphy (Berardinelli-Seip syndrome) type 3.
References in periodicals archive ?
Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling.
C], mediated by caveolin-1 to indirectly increase Fyn (a member of the Src family of tyrosine kinase) phosphorylation, governs the downstream production of NADPH-oxidize-dependent reactive oxygen species and activation of the extra-cellular regulated kinase 1/2 has been demonstrated.
Because of its pivotal role in the process of cell proliferation, apoptosis and other related signaling pathways of human tumors, caveolin-1 has been extensively studied.
The group also found that cytokines and membrane proteins, such as stromal cell-derived factor-1 and its receptor CXCR4, and caveolin-1 has a role in the metastases of IMPC.
Caveolin-1 is a natural protein found within the caveolae and influences cell signaling events, and can facilitate the development of atherosclerosis if stimulated by the inflammatory signaling network.
Binding partners to GqPCR distinct from PLC-[beta] include novel activators (Ric-8A and tubulin), candidate effectors (RhoGEFs, PI3K, GPCR kinases (GRKs), Btk, and complex regulator of G-protein signaling (RGS) proteins), regulators (RGS proteins and GRKs), and scaffold/adaptor proteins (EBP50/NHERF1, CDP/CD81, caveolin-1, and TPR1) [1, 4, 6, 50].
Shen, "Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability," Frontiers in Bioscience, vol.
caveolin-1 hypoxia-inducible factor-1a and matrix metalloproteinase expressions by RCC cells.
Immunohistochemical stainings of caveolin-1 have shown that the peripheral boundaries of EE cells are almost completely devoid of caveolin features.
Yet another mechanism contributing to endothelial dysfunction involves modification of protein-protein interactions of eNOS with heat shock protein 90 (Hsp90) and caveolin-1, decreasing binding to the former and increasing binding to the latter, resulting in reduced eNOS activity [105].
This MP effect is associated not only with decreased NOS expression, but also with overexpression of caveolin-1 (21).
Head, et al: Loss of Caveolin-1 Accelerates neurodegeneration and Aging.