CAV1

(redirected from caveolin 1, caveolae protein, 22kDa)

CAV1

A gene on chromosome 7q31.1 that encodes caveolin 1, the main scaffolding protein of caveolae plasma membranes in most cells. Caveloin 1 links integrin subunits to the tyrosine kinase FYN, an early step in coupling integrins to the Ras-ERK pathway which drives cell cycle progression; CAV1 is a tumour suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and form a stable hetero-oligomeric complex with other colocalising proteins.

Molecular pathology
CAV1 mutations are linked to congenital generalised lipodystrphy (Berardinelli-Seip syndrome) type 3.
References in periodicals archive ?
The first predicted network involves CD47, RPS6KA2, KLF6, and MSRA (Figure 1A), which are associated with the positive regulation of cellular and biological processes, chemical homeostasis, regulation of biological quality, and homeostasis (p = 3.01 x [10.sup.-19]).In the second predicted pathway (Figure 1B), ADD3, along with MSRA and CD47, may also interact independently with APOA1 (apolipo-protein A-1) and CAV1 (caveolin 1, caveolae protein, 22kDa) to regulate biological quality, homeostasis, cellular components of movement, positive regulation of biological process, and response to stimuli (p= 2.09 x [10.sup.-15]).
Nine candidates failed the initial criteria, such as assay length or unsuitable CpG site location for primer and probe placement [BCOR, BCL6 co-repressor; CAV1, caveolin 1, caveolae protein, 22kDa; CD44, CD44 molecule (Indian blood group); CDH13, cadherin 13, H-cadherin (heart); VCAN (formerly CSPG2), versican; FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32); GSK3B, glycogen synthase kinase 3 beta; PCDH17, protocadherin 17; and TAF11, TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa].