However, the caveolae-specific protein caveolin-1 has been found to interact with and to mediate [alpha]-synuclein toxicity in neuroblastoma cells  thus suggesting that the possibility that the uptake of the protein might be mediated by caveolae-mediated endocytosis
at least in neuronal cells deserves further investigation.
Previous studies suggest that the particle size of the mTAT/PEI/DNA complex (approximately 180 nm) may be the optimal size for internalization, and mTAT/PEI/DNA might be internalized by caveolae-mediated endocytosis .
Hoekstra, "Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis," Biochemical Journal, vol.
Minshall, "Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis
in endothelial cells," The Journal of Biological Chemistry, vol.
Dobson, "Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis
," PLoS ONE, vol.
It was found that the transfection efficiency of HA-modified cationic liposomes was not affected by a clathrin-mediated endocytosis inhibitor, while it was significantly decreased by inhibitors of caveolae-mediated endocytosis
, demonstrating that the latter is the main endocytosis pathway of HA-bearing lipoplexes.
Role of clathrin-and caveolae-mediated endocytosis
in gene transfer mediated by lipo- and polyplexes.
(2004) reviewed a number of different endocytic pathways for internalization of a variety of substances, including phagocytosis, macropinocytosis, clathrin-mediated endocytosis, and caveolae-mediated endocytosis
. They found in nonphagocytic cells in vitro that internalization via clathrin-coated pits prevailed for latex microspheres < 200 nm, whereas with increasing size up to 500 nm, caveolae became the predominant pathway.