Caveolins and flotillins are two families of the membrane proteins correlating with Caveolae
of the mammals (Bickel et al.
are invaginations in the wall of the endothelial cells and play a major role in cell signaling.
Endothelial NOS in cardiomyocytes is associated with caveolin-3, a muscle-specific isoform in caveolae
protein layers [7-9].
Conjugated linoleic acid alters caveolae
phospholipid fatty acid composition and decreases caveolin-1 expression in MCF-7 breast cancer cells.
In the case we describe, tumor origin from smooth muscle cells was ruled out because neoplastic cells were negative for actin and desmin (10) and did not show ultrastructural features typical of smooth muscle differentiation (myofilaments with focal densities, attachment plaques, plasmalemmal caveolae
, external lamina).
It has been shown that lipoplexes are internalized by cells solely by means of clathrin-mediated endocytosis, while polyplexes which are composed mainly of inorganic polymers, such as polyethyleneimine, are internalized both by clathrin-mediated and by caveolae
in the apical cytoplasmic membrane, as well as coated pits and mainly transparent vesicles, multivesicular bodies and lysosomes occurred in the apical cytoplasm of principal cells close related to the apical brush border (microvilli), allowing support to characterize a process of endocytosis (Figs 5 and 6).
Schnitzer, Rapid mechanotransduction in situ at the luminal cell surface of vascular endothelium and its caveolae
Closely associated with the subplasmalemmal densities are caveolae
, which appear as round, light densities budding from the subplasmalemmal densities.
Loss of caveolae
, vascular dysfunction and pulmonary defects in caveolin-1 gene-disrupted mice.
After introductory chapters on transmembrane signaling, they present 18 chapters describing methods for investigating membrane receptors and signaling, lipid raft and caveolae
in transmembrane signaling, protein-protein interaction in transmembrane signaling, rho guanosine triphosphatases and reconstitution of signaling complexes, and genomics and proteomics.
Recent advances in membrane microdomains; rafts, caveolae
, and intracellular cholesterol trafficking.