CDX2

(redirected from caudal-type homeobox protein 2)

CDX2

A gene on chromosome 13q12.3 that encodes a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates its transcription. CDX regulates the transcription of multiple genes expressed in the intestinal epithelium, both during early differentiation and as part of the maintenance of the intestinal epithelial lining of the small and large intestines.

CDX2

A gut protein used clinically in immunocytochemistry to identify adenocarcinomas of the colon and other tissues and tumors of intestinal origin.
References in periodicals archive ?
Caudal-type homeobox protein 2 (Cdx2) is a gastric epithelial cell-derived trans-differentiation factor that plays a pivotal but as yet poorly understood role in the development of "intestinal type" gastric adenocarcinoma; as such its expression serves as a harbinger of eventual development of gastric malignancy.
pylori in gastric epithelial cells causes nuclear translocation of nuclear factor-[kappa]B (NF-[kappa]B) subunits to induce expression of caudal-type homeobox protein 2 (CDX2), a critical factor for intestinal metaplasia and gastric carcinogenesis.
For example, the common immunophenotype of the classic type is cytokeratin 7-positive (CK7+)/CK20~, whereas at least one intestinal immunomarker (CK20, caudal-type homeobox protein 2 [CDX2], or mucin core protein 2 [MUC2]) is expressed in the intestinal type of BilIN.