IGF2R

(redirected from cation-independent mannose-6-phosphate receptor)

IGF2R

A gene on chromosome 6q26 that encodes a receptor for both insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). IGF2R plays a role in intracellular trafficking of lysosomal enzymes, activating transforming growth factor beta, IGF2 degradation and regulating T-cell coactivation by binding DPP4.
References in periodicals archive ?
The IGF-II receptor (IGF-IIR), which is homologous to the cation-independent mannose-6-phosphate receptor, has a high affinity for IGF-II [65].
However, in chickens, the IGF-II receptor (cation-independent mannose-6-phosphate receptor) is present, but it does not bind IGF-II, indicating that the effects of IGF-II are mediated via the IGF-I receptor (Yang et al., 1991; Zhou et al., 1995).