B and B+L activities: The activity of cathepsins
(cysteine-proteinases) B and B+L are presented in Fig.
of the A, C, D, L, and XZP classes were found as markedly more abundant in the DN groups.
Then, non-specific esterase, in conjunction with acid phosphatases, elastase, hyaluronidase, cathepsin
, collagenases and plasminogen activators, may damage the surrounding tissue .
The aim of this study was to evaluate the expression of proteins: FHIT, E-cadherin, [alpha]-catenin, [gamma]-catenin, cathepsin
B, EGF, HER-2, MMP-9, MCM-2, Bak, Bax, BID, Bcl-XL, p53, FasL, Bcl-2, caspase-8, procaspase-3 in gastric cancer cells, depending on the type of tumor by Lauren classification.
The term "Cathepsin
", was first introduced in 1929, and described the proteolytic activity of acidified tissue extracts towards hemoglobin .
Rinne, "The possible place of cathepsins
and cystatins in the puzzle of Alzheimer disease," Molecular and Chemical Neuropathology, vol.
For the inhibition studies, mouse cathepsin
L (CtsL) and Bombyx cysteine protease (BCP), both of which belong to a papain family (C1A) in the MEROPS peptidase database, were employed.
(61) Following these studies, we showed that porcine cathepsin
D, bovine rennin (later called chymosin) and acid peptidases from insectivorous plants and several fungi were also inhibited by DAN, EPNP and pepstatin, indicating a wider range of distribution of these peptidases, (62-68) and identified the DAN-reactive Asp residue in bovine chymosin.
Cystatins tightly bind and inhibit the activity of cathepsins
, if the activity of cathepsins
is not regulated it will lead to chronic diseases .
Casein was used as a substrate when defining the activity of cathepsin
D and calpain (Antipova et al., 2000).
Shi, "Cysteinyl cathepsins
and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases," Pharmacology & Therapeutics, vol.
Jessen, "Contribution of cathepsins
B, L and D to muscle protein profiles correlated with texture in rainbow trout (Oncorhynchus mykiss)" Food Chemistry, vol.