cathelicidin


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cathelicidin

An antimicrobial polypeptide found in the lysosomes of neutrophils and macrophages, which has sequence homology with the cathepsin family of cysteine proteinase inhibitors. Cathelicidin peptides have been isolated from many different species of mammals, and are produced in response to bacteria, viruses, fungi or vitamin D1,25.

cathelicidin

Any of a family of antibacterial, antifungal, and antiviral peptides produced by the cells of the innate immune system.
References in periodicals archive ?
ExpressGraft-C9T1 skin tissue has been genetically modified to express elevated levels of the human cathelicidin host defense peptide.
Infections in the urinary tract induce epithelial cells to produce cathelicidin to fight the infection.
7] The antimicrobial peptide, Cathelicidin is directly up-regulated by 1, 25[(OH).
Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin.
LL37 is the only one cathelicidin in humans, which is proteolytically generated by proteinase 3 in neutrophils and kallikrein 5 and 7 in epidermal keratinocytes.
He and others have found upregulation of the cathelicidin LL-37 and the pattern recognition receptor TLR-2.
The best known among these include lysozyme, cathelicidin and defensins (5).
Amniotic fluid cathelicidin in PPROM pregnancies: from proteomic discovery to assessing its potential in inflammatory complications diagnosis.
Gombart AF Borregaard N, Koeffler HR Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly upregulated in myeloid cells by 1,25-dihydroxy vitamin D3.
Studies have demonstrated a role for vitamin D in the expression of the human cathelicidin antimicrobial peptide, which plays a role in host defense against respiratory tract pathogens.
Although the exact mechanism remains poorly understood but it is though that the up regulation by vitamin D of NO, NADPH oxidase, cathelicidin, and autophagy mechanisms in macrophages10.
Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium," Gastroenterol.