cathelicidin


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cathelicidin

An antimicrobial polypeptide found in the lysosomes of neutrophils and macrophages, which has sequence homology with the cathepsin family of cysteine proteinase inhibitors. Cathelicidin peptides have been isolated from many different species of mammals, and are produced in response to bacteria, viruses, fungi or vitamin D1,25.

cathelicidin

Any of a family of antibacterial, antifungal, and antiviral peptides produced by the cells of the innate immune system.
References in periodicals archive ?
LL-37 is based on a human antimicrobial peptide, structurally derived from the C-terminal part of human cathelicidin antimicrobial protein 18 (hCAP18), and stimulates the function of several cell types involved in wound healing, including skin keratinocytes and fibroblasts.
LL-37, the only human member of the cathelicidin family of antimicrobial peptides.
Formation of 1,25(OH)2D within macrophages promotes the translation of a bactericidal agent, cathelicidin, the only known human protein having bactericidal properties.6 Low serum levels of 1,25(OH)2D observed in the present study maybe due to decreased conversion from its less active form or increased degradation.
Lack of cathelicidin processing in Papillon-Lefevre syndrome patients reveals essential role of LL-37 in periodontal homeostasis.
The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium.
(3,4) In Leprosy, vitamin D, through its interaction with VDR, were thought to act as immunomodulator that influences macrophage in killing the pathogen by increasing the expression of antimicrobial peptide cathelicidin. (1,5) For the immunological activity of vitamin D to happen, it needs to interact with its receptor, the VDR.
Anti-microbial peptides (AMPs; cathelicidin LL37, human neutrophil peptide-1 and human beta defensins) are a key component of innate immunity against pathogens and play a role in the destruction of pathogens engulfed by phagocytic cells.40 AMPs are activated by Mtb infection.41 Studies have revealed reduced expression of AMPs in DM patients with latent and active TB when compared with non-DM patients.42 These indicate an association between down-regulation of AMPs and their impact on DM and TB susceptibility.
It is not simply a vitamin, but is a neuroregulatory steroidal hormone regulating the ability of the body to fight infection and producing 200 antimicrobial peptides, including cathelicidin, a natural broad-spectrum antibiotic.
Candidacidal activity of selected ceragenins and human cathelicidin LL-37 in experimental settings mimicking infection sites.
In fact, studies have shown that vitamin D increases the production of a protein called cathelicidin, which protects the healthy skin from infections and bacteria.
The first is cathelicidin (LL37), derived from keratinocyte and may be considered as an autoantigen since it is an antimicrobial peptide.