ADRB2

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ADRB2

A gene on chromosome 5q31-q32 that encodes beta-2-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB2 binds epinephrine with a 30-fold greater affinity than it does with norepinephrine.
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Oregon Health & Science University (Portland, OR) has patented mammalian catecholamine receptor proteins and genes that encode such proteins.
We hypothesize that long-term exposure to air pollution is associated with chronic release of catecholamines, which could lead to desensitization or down-regulation of catecholamine receptors (Hausdorff et al.
Magnesium sulfate inhibits catecholamine release from the catecholamine-secreting tumor and blocks peripheral catecholamine receptors [9].
Catecholamine induced myocardial damage progresses as the demand of oxygen increases with increased metabolic rate by stimulation of catecholamine receptors and a mismatch occurs in myocardial perfusion [3].
Stress resilience may be enhanced through the regulation of NE system responsiveness, which is mediated through effects on the NE transporter on catecholamine receptors (i.e., [alpha]2 adrenoreceptors), as well as interactions between the NE and other neurobiologic systems, such as the dopamine and serotonin systems (Krystal and Neumeister 2009).
In addition to octreotide, selective blockade of catecholamine receptors might prevent carcinoid crisis in stressful situations.