This research service focusses on existing therapeutics and the product pipeline for the treatment of Parkinson's disease using dopamine replacement therapies, dopamine agonists, Monoamine Oxidase (MAO) inhibitors, Catechol O-methyltransferase
(COMT) inhibitors and other pharmacological approaches of current global interest.
Cytochrome P450 CYP1B1 and catechol O-methyltransferase
(COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population.
In an open-label pilot study of 36 marijuana-dependent individuals, 12 weeks of treatment with the catechol O-methyltransferase
inhibitor entacapone significantly decreased craving for marijuana in 19 (53%) of the study participants.
Other medications that can be associated with psychosis include monoamine oxidase-[beta] inhibitors, dopamine agonists, and catechol O-methyltransferase
Methylation pharmacogenetics: catechol O-methyltransferase
, thiopurine methyltransferase, and histamine N-methyltransferase.
In contrast, PD patients are treated with a cocktail of drugs but predominantly with dopaminergic drugs such as Levodopa and/or dopamine agonists either as a monotherapy or in combination with catechol O-methyltransferase
(COMT) inhibitors or monoamine oxidase (MAO) inhibitors.
(COMT) INHIBITORS Useful adjuncts to levodopa, greatly reducing "on-off" fluctuations.
Plasma circulating catechol estrogens are known to be rapidly metabolized by erythrocytic catechol O-methyltransferase
to the corresponding guaiacol estrogens, such as 2-methoxyestrone or 2-methoxyestradiol (7,8).