catechol O-methyltransferase

cat·e·chol O-meth·yl·trans·fer·ase

a transferase that catalyzes the methylation of the hydroxyl group at the 3 position of the aromatic ring of catechols, including the catecholamines norepinephrine and epinephrine (thus, converting to normetanephrine and metanephrine, respectively), the methyl group coming from S-adenosyl-l-methionine. An important step in the catabolism of the catecholamines.
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References in periodicals archive ?
Research findings have shown that low levels of proline dehydrogenase (PRODH) and catechol O-methyltransferase (COMT) in DGS are responsible for the phenotypic representation of psychotic disorders.
(2003) Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine.
Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population.
BOCA RATON, FLA.--In an open-label pilot study of 36 marijuana-dependent individuals, 12 weeks of treatment with the catechol O-methyltransferase inhibitor entacapone significantly decreased craving for marijuana in 19 (53%) of the study participants.
Other medications that can be associated with psychosis include monoamine oxidase-[beta] inhibitors, dopamine agonists, and catechol O-methyltransferase inhibitors.
CATECHOL O-METHYLTRANSFERASE (COMT) INHIBITORS) Useful adjuncts to levodopa, greatly reducing "on-off" fluctuations.
ropinirole 9-24 $6.21 (Requip) mg/day (5 mg t.i.d.) pramipexole 1.5-4.5 $6.75 (Mirapex) mg/day (1 mg t.i.d.) pergolide 0.5-1.5 $5.64 (Permax) mg/day (0.25 t.i.d.) bromocriptine 15-50 $22.44 (Parlodel) mg/day (15 mg b.i.d.) CATECHOL O-METHYLTRANSFERASE (COMT) INHIBITORS Useful adjuncts to levodopa, greatly reducing "on-off" fluctuations.
Another catechol O-methyltransferase enzyme inhibitor thought to be safer is expected to reach the market soon.
Plasma circulating catechol estrogens are known to be rapidly metabolized by erythrocytic catechol O-methyltransferase to the corresponding guaiacol estrogens, such as 2-methoxyestrone or 2-methoxyestradiol (7,8).