catalytic triad


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to catalytic triad: Oxyanion hole

catalytic triad

The enzymatically active mechanism found in serine proteases, consisting of three amino acids SER-HIS-ASP (serine, histidine, and aspartic acid).
See also: triad
References in periodicals archive ?
The next step was obtain the properties that allow Ops adsorption hence fullerenes with aromatic valences substitutes by groups based on the side chain of AChE's catalytic triad composed by serine (Ser), glutamate (Glu) and histidine (His).
The molecular interaction analysis indicates Blasticidin S hydrochloride as potent inhibitor of LGMN owing to its interaction with the catalytic triad amino acids residues and nine hydrogen bonds at the active site.
The 3 catalytic triads (His72, Asp118, and Ser216) for serine protease activity were highly conserved in these trypsin-like proteases.
Likewise, the ligand S1 formed 2 hydrogen bonds on catalytic site docking (Table 4), one between the O1 atom of the ligand and Ne[epsilon] of the HIS 447 residue; main residue of catalytic triad is at a bond length of 3.34 [Angstrom].
All six families appear to use the same, two-step reaction mechanism based on a catalytic triad of residues (usually Ser-His-Asp/Glu) that generates a charge relay system and a highly nucleophilic serine.