catalytic triad


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Related to catalytic triad: Oxyanion hole

catalytic triad

The enzymatically active mechanism found in serine proteases, consisting of three amino acids SER-HIS-ASP (serine, histidine, and aspartic acid).
See also: triad
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References in periodicals archive ?
The next step was obtain the properties that allow Ops adsorption hence fullerenes with aromatic valences substitutes by groups based on the side chain of AChE's catalytic triad composed by serine (Ser), glutamate (Glu) and histidine (His).
Computational Studies of Fullerene Derivatives as Pesticide Captors
The molecular interaction analysis indicates Blasticidin S hydrochloride as potent inhibitor of LGMN owing to its interaction with the catalytic triad amino acids residues and nine hydrogen bonds at the active site.
Screening and Identification of Microbial Derivatives for Inhibiting Legumain: An In silico Approach
The 3 catalytic triads (His72, Asp118, and Ser216) for serine protease activity were highly conserved in these trypsin-like proteases.
RNA interference mediated serine protease gene (Spbtry1) knockdown affects growth and mortality in the soybean pod borer (Lepidoptera: Olethreutidae)
Likewise, the ligand S1 formed 2 hydrogen bonds on catalytic site docking (Table 4), one between the O1 atom of the ligand and Ne[epsilon] of the HIS 447 residue; main residue of catalytic triad is at a bond length of 3.34 [Angstrom].
Virtual screening and biological evaluation of piperazine derivatives as human acetyl-cholinesterase inhibitors
All six families appear to use the same, two-step reaction mechanism based on a catalytic triad of residues (usually Ser-His-Asp/Glu) that generates a charge relay system and a highly nucleophilic serine.
Computational Analysis of an Acidic Lipase of Tribolium castaneum
Catalytic Triads as the Molecular Sites of ACR Action
Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry
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