If the daily energy balance is positive, new energy reserves are stored as tissue; if negative, a shorebird catabolizes
body tissue to make up the difference.
Research by Pariza's team now suggests that CLA may also prove beneficial in treating cachexia, a wasting that occurs when the body catabolizes
-- burns up -- muscle in an attempt to meet the high energy demands of fighting certain chronic diseases, such as malaria or cancer.
Circulating endothelin-1 is increased in PE relative to normal pregnancy and indoleamine 2,3-dioxygenase, an enzyme that catabolizes
tryptophan, is reduced, diminishing the inhibitory action of tryptophan depletion and resulting in immune cell activation.
The treatment with heme (10 [micro]M) triggers an increase in iNOS expression with the concomitant decrease in arginase expression, an enzyme that catabolizes
arginine, the main substrate for NOS (Figure 4(a)).
myo-inositol, a metabolite depleted in diabetes mellitus.