catabolic pathway

catabolic pathway

A series of metabolic reactions leading to breakdown of a complex organic molecule to a simpler ones, with release of energy. Cf Anabolic pathway.
References in periodicals archive ?
Alkaptonuria is a rare metabolic disorder in the phenylalanine and tyrosine catabolic pathway which is characterized by the excessive excretion of homogentisic acid in the urine, ochronosis, and debilitating arthritis of the spine and large joints.
The loss of this enzyme shuts down the glucose anabolic pathway and promotes the glucose catabolic pathway, leading to a large amount of glucose entering the tumor cells and thus "feeding" the aggressive cancer.
putida strains in which the chromosome has been edited and deleted of most unnecessary genomic elements, 2 introduction and optimization of an efficient glycolytic catabolic pathway in thereby obtained strains, and 3 strengthening the stress resistance of these P.
Glutaric aciduria type 1 is the most common OA in South Africa and is caused by AR deficiency of glutaryl-CoA dehydrogenase (GCDH), a critical enzyme in the infantile neuronal lysine catabolic pathway.
The steroid catabolic pathway of the intracellular pathogen Rhodococcus equi is important for pathogenesis and a target for vaccine development.
DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zetal and maleylacetoacetate isomerase (GSTzl/ MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.
MSUD is a secondary to an enzyme defect in the catabolic pathway of the branched-chain amino acids leucine, isoleucine, and valine.
The assembled pathway must outline the degradation of the target compound all the way to the point at which its metabolites can enter the tricarboxylic acid (TCA) cycle, the central catabolic pathway of life, thereby becoming a useful carbon and/or energy source.
Mitochondrial fatty acid oxidation (FAO) is a catabolic pathway that supplies energy for the normal physiologic functioning of many tissues when glucose is unavailable, and it also supplies energy for some tissues even when glucose is available (1, 2).
Increased C4-acylcarnitine may reflect either of two very different disorders: isobutyryl-CoA dehydrogenase deficiency in the catabolic pathway of valine (increased isobutyrylcarnitine) or short-chain acyl-CoA dehydrogenase deficiency in fatty acid (3-oxidation (increased butyrylcarnitine).
The deficiency of one of the lysosomal enzymes involved in the catabolic pathway of glycoproteins leads to the accumulation of undegraded oligosaccharides in lysosomes and increased urinary excretion of carbohydrate material produced by the cytolysis of sick cells.