process Modification-dependent protein catabolic
Fusobacteriumnucleatum catabolizes glutamate whereas zinc inhibits this catabolic
reaction and causes inhibition of growth; along with this it also prevents the growth of Prevotellaintermedia by inhibiting the catabolism of aspartyl-aspartate and aspartate.
1,4) Infection, prolonged fasting, or trauma induce a catabolic
state that, in these disorders, results in severe metabolic acidosis with increased anion gap, hyperammonemia, hypoglycemia, and electrolyte imbalances that may lead to coma or death.
14) Sato et al demonstrated this contributes to a net catabolic
state with an uncorrected hyperglycemia.
Weight-training during fasting hours can create too much muscle breakdown and loss of lean mass, and can cause a significant rise in the catabolic
hormone cortisol and may lead to dehydration.
If the catabolic
phase is prolonged and/or the body is not provided with adequate nutrient supplies, then the body can enter a Protein Energy Malnutrition (PEM) state.
The AMPK negatively regulates the anabolic pathway, for instance lipogenesis or triglycerides synthesis, and positively regulates the catabolic
pathways like lipid oxidation.
The administration of the extract also induced changes in the cells suggestive of autophagy (a catabolic
process in which a cell degrades its own components), possibly induced by increased levels of histone deacetylase activity.
Alkaptonuria is a rare metabolic disorder in the phenylalanine and tyrosine catabolic
pathway which is characterized by the excessive excretion of homogentisic acid in the urine, ochronosis, and debilitating arthritis of the spine and large joints.
The loss of this enzyme shuts down the glucose anabolic pathway and promotes the glucose catabolic
pathway, leading to a large amount of glucose entering the tumor cells and thus "feeding" the aggressive cancer.
The progress of these changes seems to result in enhanced oxidative stress, decreased ATP production, and collapse of the cellular catabolic
machinery, which eventually is incompatible with survival.