cast nephropathy


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cast nephropathy

Deterioration in kidney function resulting from the deposition of immunoglobulin light chains (and other proteins) in the distal kidney tubules.
Synonym: myeloma kidney.
See also: nephropathy
References in periodicals archive ?
European trial of free light chain removal by extended haemodialysis in cast nephropathy (EuLITE): A randomized control trial.
Studies in patient with multiple myeloma and renal failure due to myeloma cast nephropathy (MYRE)
Following evidence in animal model that aciduria increases the nephrotoxicity of Bence Jones protein independently of urinary flow rate [88,89], alkalinization of the urine through oral bicarbonate has been recommended in patients with multiple myeloma and Bence Jones proteinuria to prevent or treat myeloma cast nephropathy.
Booker, "Pathobiology of cast nephropathy from human Bence Jones proteins," The Journal of Clinical Investigation, vol.
Cast nephropathy occurs when the abnormally high levels of serum free light chains are filtered through the glomerulus.
5-11) There are some morphologic patterns that are readily recognizable at the light microscopic level, especially when the manifestations are florid, including that of myeloma cast nephropathy, nodular glomerulosclerosis associated with light or heavy chain deposition disease, and light and heavy chain (AL and AH) amyloidosis.