Contract notice: Supply of the drug caspofungin
for all osakidetza service organizations
In Brazil, the following antimicrobials are considered acceptable for use in OPAT: amikacin, gentamicin, ceftriaxone, cefepime, ceftazidime, ceftaroline, ertapenem, linezolid (when formulation for oral use is not available), tigecycline, daptomycin, teicoplanin, vancomycin, amphotericin B (lipid formulations), caspofungin
, anidulafungin, micafungin and voriconazole (when formulation for oral use is not available).
Treatment, if clinically indicated, includes an echinocandin such as micafungin, anidulafungin, and caspofungin
at standard dosing.
AST YS 07 Cards were used as per to manufacturer's instructions, and results were evaluated for activity against fluconazole, voriconazole, caspofungin
, micafungin, amphotericin B, and flucytosine.
He was given imipenem and cilastatin sodium, vancomycin, and caspofungin
with reduced dose of corticosteroid.
An Etest was used in accordance with the manufacturer's instructions to specify the amphotericin B (AMB), fluconazole, voriconazole, ketoconazole, itraconazole, anidulafungin, caspofungin
, and flucytosine (FLU) susceptibilities of the species.
Lidocaine (LD) is an anesthetic used in clinical medicine, which showed antifungal activity has already been described, alone or in synergy with antifungal agents like amphotericinB, itraconazole, voriconazole, and caspofungin
, however it is important to emphasize that the use must be topical due to toxicity (Judd & Martin, 2009; Palmeira-de-Oliveira et al.
The antifungal susceptibility test done at Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh by CLSI M38-A2 protocol showed the MIC of amphotericin B, fluconazole, voriconazole, itraconazole, posaconazole, caspofungin
, anidulofungin and micafungin to be 0.
Evaluation and use of Caspofungin
and Quinolones in newborn critical).
Of the latter, 8 received fluconazole, 2 caspofungin
, 1 fluconazole and caspofungin
, and 1 fluconazole, caspofungin
, and anidulafungin (given at a different time periods) (Table).
sup] Treatment guidelines for native valve Candida endocarditis strongly recommended surgical treatment within 1 week, combined with antifungal treatment consisting of liposomal amphotericin B or caspofungin
for 6-8 weeks, with or without additional flucytosine, followed by fluconazole.
Other drugs include itraconazole, caspofungin
acetate and voriconazole.