caspases


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Related to caspases: apoptosis, cytochrome c, Bcl-2

caspases

(kas'pās-ĕz),
Proteolytic cleavage products of the protein's procaspases that are responsible for cleaving and activation of additional procaspases into more caspases, thus resulting in a cascade of proteolytic activity the final result of which is apoptosis of the cell.
[cysteinyl aspartate specific proteinase]

caspases

A family of proteases, some of which are involved in APOPTOSIS.
References in periodicals archive ?
Caspase requirement for neuronal apoptosis and neurodegeneration.
In the following steps, caspase will activate Caspases 6 and 7 resulted apoptosis mechanism through extrinsic pathways.
Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis.
The involvement of apoptotic pathways was evaluated through caspase analysis and multiple cytotoxicity assays.
Hence, acute pharmacological inhibition of caspases, in particular caspase-3, still holds promise as a treatment for ischemia-related diseases where the cell death stimulus is only present for a short period of time and clearly differs from the long-term effects of caspase-3 deficiency.
Cellular alterations such as chromatin condensation and caspase cascade have characterized apoptotic cells.
The findings could lead to the development of nonantibiotic drugs designed to fight certain bacterial infections by activating these caspases.
Caspases (cysteine aspartyl proteases) are upregulated in the lymphocytes of sepsis patients, which may hasten the death of lymphocytes (42).