requirement for neuronal apoptosis and neurodegeneration.
In the following steps, caspase
will activate Caspases
6 and 7 resulted apoptosis mechanism through extrinsic pathways.
are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis.
3 is an "effector" marker; associated with initiation of apoptotic signaling pathway.
The involvement of apoptotic pathways was evaluated through caspase
analysis and multiple cytotoxicity assays.
Hence, acute pharmacological inhibition of caspases
, in particular caspase
-3, still holds promise as a treatment for ischemia-related diseases where the cell death stimulus is only present for a short period of time and clearly differs from the long-term effects of caspase
Cellular alterations such as chromatin condensation and caspase
cascade have characterized apoptotic cells.
The findings could lead to the development of nonantibiotic drugs designed to fight certain bacterial infections by activating these caspases
(cysteine aspartyl proteases) are upregulated in the lymphocytes of sepsis patients, which may hasten the death of lymphocytes (42).
involved in ER stress-mediated cell death.
are cysteine proteases that mediate apoptotic cell death, including neurons.
We demonstrated that EBV-induced apoptosis was dependent on activation of caspases