CASP5

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CASP5

A gene on chromosome 11q22.2-q22.3 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of cell apoptosis; overexpression of activated CASP5 induces apoptosis in fibroblasts. CASP5 is an initiator type caspase, which is activated by, and interacts, with upstream adaptor molecules through CARD and DED protein–protein interaction domains; CASP5 expression is regulated by IFN-gamma and lipopolysaccharides.
References in periodicals archive ?
Inflammatory caspases (caspase-1, caspase-4, caspase-5, and caspase-11) are critical for immune defenses [34-36].
In human cells, caspase-4 and caspase-5 performed the function of mouse caspase-11.
The FAA treatment was found to decrease the activity of caspase-5 in MCF-7, while in MDA-MB-231 cells it increased at I[C.sub.25] of FAA.
On the other hand, caspase-1 and caspase-5 are called inflammatory caspases, but they are also involved in the hydrolysis of procaspase-3 to the activated caspase-3 [29].
Iakovidou-Kritsi, "Indication of participation of caspase-2 and caspase-5 in mechanisms of human cervical malignancy," International Journal of Gynecological Cancer : official journal of the International Gynecological Cancer Society, vol.
Human caspase1, caspase-4, and caspase-5 are critical mediators in the pyroptosis process [7].
To investigate which caspase is involved in [DELTA]nleF-induced inflammatory cell death, we used small interfering RNA (siRNA) to knock down caspase-1, caspase4, or caspase-5 in HT29 cells and then infected the cells with EDL933, [DELTA]nleF, or [DELTA]nleF/nleF.
By using specific siRNA to knock down the expression of caspase-1 or caspase-4 or caspase-5, we further demonstrated that NleF prevented inflammatory cell death during EHEC infection by targeting caspase-4 (Figure 3(a)).
Mortellaro, "Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes," Nature Communications, vol.
Iversen, "Caspase-5 expression is upregulated in lesional psoriatic skin," The Journal of Investigative Dermatology, vol.
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