Inflammatory caspases (caspase-1, caspase-4, caspase-5, and caspase-11) are critical for immune defenses [34-36].
In human cells, caspase-4 and caspase-5 performed the function of mouse caspase-11.
The FAA treatment was found to decrease the activity of caspase-5 in MCF-7, while in MDA-MB-231 cells it increased at I[C.sub.25] of FAA.
On the other hand, caspase-1 and caspase-5 are called inflammatory caspases, but they are also involved in the hydrolysis of procaspase-3 to the activated caspase-3 .
Iakovidou-Kritsi, "Indication of participation of caspase-2 and caspase-5 in mechanisms of human cervical malignancy," International Journal of Gynecological Cancer : official journal of the International Gynecological Cancer Society, vol.
Human caspase1, caspase-4, and caspase-5 are critical mediators in the pyroptosis process .
To investigate which caspase is involved in [DELTA]nleF-induced inflammatory cell death, we used small interfering RNA (siRNA) to knock down caspase-1, caspase4, or caspase-5 in HT29 cells and then infected the cells with EDL933, [DELTA]nleF, or [DELTA]nleF/nleF.
By using specific siRNA to knock down the expression of caspase-1 or caspase-4 or caspase-5, we further demonstrated that NleF prevented inflammatory cell death during EHEC infection by targeting caspase-4 (Figure 3(a)).
Mortellaro, "Human caspase-4 and caspase-5
regulate the one-step non-canonical inflammasome activation in monocytes," Nature Communications, vol.
expression is upregulated in lesional psoriatic skin," The Journal of Investigative Dermatology, vol.