Summary: TEHRAN (FNA)- Researchers have discovered using mice and human clinical specimens that caspase-2
, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive liver condition.
Apoptotic initiators (such as caspase-2
, -8, -9, and -10) activate the downstream cascade of necroptosis with the help of the adapter proteins.
The induction of caspase-2
activity increased significantly in MDA-MB-231, but not in MCF-7.
Other studies have also revealed the importance of caspase-2
and caspase-6 in causing the death of retinal ganglion cells following optic nerve transections [41-43].
Caspase2 has been reported as an initiator caspase, its role is very special in apoptosis since caspase-2
gene produces several alternative splicing isoforms (Bouchier-Hayes and Green, 2012).
Matarrese et al., "A key role for caspase-2
and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (Cladribine) and 2-chloro-adenosine in human astrocytoma cells," Molecular Pharmacology, vol.
Washington, June 26 ( ANI ): Researchers at Columbia University Medical Center (CUMC) have confirmed that a protein called caspase-2
is a key regulator of a signaling pathway that leads to cognitive decline in Alzheimer's disease.
This invention provides a method of inducing apoptosis, a method of determining physiological effects, a method for identifying an apoptosis inducing or inhibiting compound, a method for screening cDNA libraries of said polypeptide, a method to induce caspase-2
and caspase-3 activity to cleave poly (ADP-ribose) polymerase and fragment nuclear DNA in a cell, a method to inhibit NF-?B activation in a cell, a method to detect a neurodegenerative disease, a method of producing the isolated human HGR74 protein into a suitable vector, a pharmaceutical composition comprising a purified polypeptide capable of binding a p75NTR receptor and a pharmaceutically acceptable carrier and a method of identifying a compound which is an apoptosis inhibitor.
Executioner caspases (caspase-3, caspase-6, and caspase-7) and upstream effector caspases (caspase-2
, caspase-8, caspase-9, and caspase-10) are well known as mediators in AD brains .
The cell-permeable pan-caspase inhibitor, the caspase-3 specific inhibitor, the caspase-9 specific inhibitor, the caspase-8 specific inhibitor, and the caspase-2
specific inhibitor were purchased from (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA).
The researchers, from The University of Texas Health Science Center San Antonio, found that neurons lacking a substance called caspase-2
were better able to withstand pesticide-induced damage to energy centers known as mitochondria.