On the contrary, IL-4/13 significantly decreased, while IFN-a increased the expression of LEKTI and caspase-14. Similar trends were observed in AD lesions.
Here, we examined the expression of FLG and related serine proteases (KLK5, KLK7, matriptase, and CAP1), cysteine protease caspase-14, and LEKTI by immunohistochemical staining in acute and chronic lesions of AD.
Origins have identified that persistently dry skin often lacks in the enzyme Caspase-14
, so their Make A Difference Plus + Rejuvenating Serum, PS34, creates a moisture reservoir within the layers of skin to rectify this.
At 2% use levels, the BEE-laced cream increased the expression of Caspase-14
(which protects skin from UVB) and hyaluronic acid in the tissue models.
The protein caspase-14 is crucial in maintaining the 'stratum corneum', a layer of flattened dead cells that acts as a protective barrier for our skin, their research has shown.
The mice without caspase-14 had skin that was shiny and wrinkled from dehydration due to the loss of water via the skin and was also highly sensitive to damage from UVB radiation.
Thomas Jefferson University (Philadelphia, PA) has patented an isolated nucleic acid molecule encoding a caspase-14
polypeptide or functional fragment thereof, a vector that contains the nucleic acid molecule and a host cell that contains the vector.
Caspaline 14 is a synthetic peptide designed to target and boost the expression of caspase-14, a cysteine protease linked to skin softness and suppleness.
By boosting caspase-14, which has been linked with cornifying epithelial tissue, such as the skin, and influencing terminal keratinocyte differentiation and formation of the skin's barrier function, Caspaline 14 may help limit skin damage from UV, according to the company.
Tests showed that the product boosts keratinocyte differentiation by stimulating the expression of caspase-14
and improves intercellular connections by boosting the expression of connexin 43, a major component of gap junctions involved in cell-to-cell communication.
The enzyme, caspase-14, is said to be activated during the differentiation of keratinocytes into corneocytes, which forms the stratum corneum, the skin's protective layer.
Caspase-14 may encourage keratinocyte proteins to mature or it may remove nuclei from the corneocytes," stated Dr.