CASP10

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CASP10

A gene on chromosome 2q33-q34 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution-phase of cell apoptosis, as well as various stages of embryological development. CASP10 is an initiator-type caspase which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains. It cleaves and activates caspase-3, -4, -6, -7, -8 and -9, is recruited to Fas- and TNFR-1 receptors in a FADD-dependent manner, and may participate in the granzyme B apoptotic pathways. It is expressed in most tissues. CASP10 is also a less preferred gene symbol for what is now designated PPIG, see there. 

Molecular pathology
Defects in CASP10 have been linked to gastric cancer, non-Hodgkin lymphoma and autoimmune lymphoproliferative syndrome type 2A.
References in periodicals archive ?
Together with caspase-10 it belongs to the so-called initiator caspase group, and is important effector activation competent.
FasL expression was up-regulated by taiwanin A at both the transcriptional and translational levels, following the activation of caspase initiator caspase-10 and effector caspase-7.
In the extrinsic way, the apoptotic signal begins by the union of extra cellular ligands to the surface of cell receptors, resulting in a recruitment of the cytosolic adapter of proteins, that activates the caspase-8 or caspase-10 initiator, and subsequently, the caspases effectors -3, -7 and possibly -6.

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