caspase 3

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caspase 3

A 32-kD cysteine-aspartic acid protease encoded by CASP3 on chromosome 4q34, which is related to ICE–IL-1 beta converting enzyme, and plays a key role in the execution-phase of apoptosis via poly-(ADP)-ribose-polymerase cleavage. Caspase 3 cleaves and activates caspases 6, 7 and 9, and is itself processed by caspases 8, 9 and 10. It is the key caspase in cleaving amyloid-beta 4A precursor protein, which is linked to neuronal death in Alzheimer's disease.

Normal expression
Caspase 3 is expressed on germinal centre B cells, plasma cells, and on scattered activated B cells.

Abnormal expression
Some non-Hodgkin lymphomas.
References in periodicals archive ?
As it can be seen in diagram 1, enzyme protein level of caspase 3 indicated increase in gastric cancer tissue of both groups after three curses of chemotherapy with Cz's-Platin.
The "Mos-iCsp3" mouse (for "mosaic inducible caspase 3 mouse") is engineered so that administration of a drug initiates destruction of cells in specifically designated tissues, explains Dr.
The altered expression of Bcl-2 family member proteins triggered the release of cytochrome-C and activation of initiator capsase 9 followed by activation of effector caspase 3.
Caspase 1 and caspase 3 inhibition protects OLGs against TNF-[alpha]-induced apoptosis [38-41].
Involvement of caspase 3 and caspase 8 was shown together with the down-regulation of Bcl-2 protein (Akao et al.
This enzyme acts late in a cell's suicide program, so the investigators hypothesized that inhibiting XIAP's interaction with caspase 3 would guarantee a cancer cell's suicide.
Example apoptosis-inducing genes include caspase 3, caspase 4, caspase 5, Granzyme B.
The substrate specificity of caspase 8 is different from other caspases, for example caspase 3," noted Joe Wu, Ph.
Primary antibodies of ASK-1, JNK, cyto c, caspase 3, bcl-2, PARP together with all secondary antibodies were purchased from Cell Signaling Technology (Danvers, MA, USA).
The citation is: "MTS-conjugated, anti-active caspase 3 antibodies inhibit actinomycin D-induced apoptosis", Y Zhao, T L Brown, H Kohler and S.
Researchers have described caspase 3 as the "executioner caspase" since the activation of caspase 3 commits a cell to undergo apoptotic cell death.

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