caspase 3


Also found in: Wikipedia.

caspase 3

A 32-kD cysteine-aspartic acid protease encoded by CASP3 on chromosome 4q34, which is related to ICE–IL-1 beta converting enzyme, and plays a key role in the execution-phase of apoptosis via poly-(ADP)-ribose-polymerase cleavage. Caspase 3 cleaves and activates caspases 6, 7 and 9, and is itself processed by caspases 8, 9 and 10. It is the key caspase in cleaving amyloid-beta 4A precursor protein, which is linked to neuronal death in Alzheimer's disease.

Normal expression
Caspase 3 is expressed on germinal centre B cells, plasma cells, and on scattered activated B cells.

Abnormal expression
Some non-Hodgkin lymphomas.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
This is expected, because caspase-8 is a major initiation in death receptor signaling; active caspase-8 leads to the activation of downstream caspases, including caspase 3 (Chen and Wang, 2002).
Tylophora alkaloids induced apoptosis in K562 cells with characteristic apoptotic features like nuclear condensation, apoptotic body formation, flipping of membrane phosphatidylserine, activation of caspase 3 and release of mitochondrial cytochrome c.
The primary antibodies used to detect MLKL (37705S), cleaved caspase 3 (9661s), and caspase 3 (9662s) were obtained from Cell Signaling Technology (USA).
Objective: To determine the applicability of urinary caspase 3 enzyme and TNF-a as biomarkers in children with ureteropelvic junction obstruction (UPJO).
As shown in the Figure 4a, the Caspase 3 activities were significantly increased in 1.6 mg/l of the PFOS single-treatment, 0.8 mg/l of the PFOS and 1.6 mg/l of the PFOS joint exposure groups compared with that in the control (p < 0.05).
Xie et al., "Quercetin induces apoptosis by activating caspase 3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells," Acta Biochimica of Biophysica Sinica, vol.
Sun et al., "Prevention of renal ischemic injury by silencing the expression of renal caspase 3 and caspase 8," Transplantation, vol.
The following primary antibodies were used: WNV (Envelope protein; Abcam, Cambridge, MA), Iba-1 (Wako Chemicals, Richmond, VA), CD3 and Mac-3 (BD Biosciences, San Jose, CA), Fas (X-20, Santa Cruz Biotechnology, Dallas, TX), caspase 3 (Asp175, clone 5A1E, Cell Signaling, Danvers, MA), and PYCARD ASC-speck (MyBiosource, San Diego, CA).
The caspase activity in treated MCF-7 revealed that FAA increased the activation of caspases 8 and 6 in all three used concentrations, while in only one concentration it increased caspase 9 (only in IC75) and caspase 3 (only in IC25) activities.
The activation of ER-resident caspase 12 directly results in the activation of cytoplasmic caspase 3 during ER stress-induced apoptosis [19, 20].
MCF-7 cancer cell lines are characterized by resistance chemotherapeutic agents, [17,18] responsive estrogen receptors (ER+), overexpression of Bcl-2, [19,20] and with no expression of Caspase 3. [21,22] Stimulation of ER could increase P-gp concentration.

Full browser ?