caseous necrosis

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Related to caseous necrosis: granuloma, tuberculosis, Fibrinoid necrosis


 [nĕ-kro´sis, ne-kro´sis] (Gr.)
the morphological changes indicative of cell death caused by enzymatic degradation.
aseptic necrosis necrosis without infection or inflammation.
acute tubular necrosis acute renal failure with mild to severe damage or necrosis of tubule cells, usually secondary to either nephrotoxicity, ischemia after major surgery, trauma (see crush syndrome), severe hypovolemia, sepsis, or burns. See also lower nephron nephrosis.
Balser's fatty necrosis gangrenous pancreatitis with omental bursitis and disseminated patches of necrosis of fatty tissues.
bridging necrosis septa of confluent necrosis bridging adjacent central veins of hepatic lobules and portal triads characteristic of subacute hepatic necrosis.
caseous necrosis caseation (def. 2).
central necrosis necrosis affecting the central portion of an affected bone, cell, or lobule of the liver.
cheesy necrosis caseation (def. 2).
coagulation necrosis death of cells, the protoplasm of the cells becoming fixed and opaque by coagulation of the protein elements, the cellular outline persisting for a long time.
colliquative necrosis liquefactive necrosis.
fat necrosis necrosis in which fat is broken down into fatty acids and glycerol, usually occurring in subcutaneous tissue as a result of trauma.
liquefactive necrosis necrosis in which the necrotic material becomes softened and liquefied.
massive hepatic necrosis massive, usually fatal, necrosis of the liver, a rare complication of viral hepatitis (fulminant hepatitis) that may also result from exposure to hepatotoxins or from drug hypersensitivity.
moist necrosis necrosis in which the dead tissue is wet and soft.
postpartum pituitary necrosis see postpartum pituitary necrosis.
selective myocardial cell necrosis myofibrillar degeneration.
subcutaneous fat necrosis of newborn a benign, self-limited disease affecting term newborns and young infants, characterized by circumscribed, indurated, nodular areas of fat necrosis. It is thought to be related to trauma on bony prominences during delivery, hypothermia, asphyxia, or maternal diabetes; it usually resolves spontaneously by 2 to 4 weeks with no scarring. Called also adiponecrosis neonatorum or subcutanea.
Zenker's necrosis hyaline degeneration and necrosis of striated muscle; called also Zenker's degeneration.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ca·se·ous ne·cro·sis

, caseation necrosis
necrosis characteristic of certain inflammations (for example, tuberculosis, histoplasmosis), which represents necrosis with loss of separate structures of the various cellular and histologic elements; affected tissue manifests the friable, crumbly consistency and dull, opaque quality observed in cheese.
Farlex Partner Medical Dictionary © Farlex 2012


An obsolete term for:
(1) Caseation (necrosis); 
(2) Precipitation of casein (the phosphoprotein family found in mammalian milk);
(3) Vomiting of milk curds by infants; popularly, “spit up”.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ca·se·ous ne·cro·sis

, caseation necrosis (kā'sē-ŭs nĕ-krō'sis, kā-sē-ā'shŭn)
Necrosis characteristic of certain inflammations (e.g., tuberculosis, histoplasmosis); affected tissue manifests the friable, crumbly consistency and dull, opaque quality observed in cheese.
Synonym(s): caseous degeneration.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

ca·se·ous ne·cro·sis

, caseation necrosis (kā'sē-ŭs nĕ-krō'sis, kā-sē-ā'shŭn)
Necrosis characteristic of some inflammations; affected tissue manifests the crumbly consistency and dull opaque quality of cheese. Also called caseous degeneration.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Caption: Figure 4 Histopathology showing tuberculous granuloma with caseous necrosis.
In disseminated tuberculosis, foci of specific lesions (granulomas) comprised large central zones of caseous necrosis surrounded by a few inflammatory cells.
Tuberculosis (Tb) is the most important infectious cause of death in the world that is histologically characterized by a chronic granulomatous inflammation and caseous necrosis (Bloom & Murray, 1992).
When inbred and outbred animals were compared histologically, inbred animals showed more caseous necrosis, more visible bacilli and fewer epitheleoid cells, suggesting that inbred animals were more susceptible to TB than the outbreds.
A biopsy revealed a chronic granulomatous dermatitis with caseous necrosis. Although a search for M.
For cytopathological diagnosis, presence of epithelioid cell clusters with caseous necrosis has been commonly used to define a positive smear.
A tissue sample was collected from the lesion by endoscopy, and the intraoperative histopathological examination revealed granulation tissue composed of caseous necrosis and Langerhans giant cells, revealing Mycobacterium species to be the causative pathogen.
Caption: Figure 1: Lymph node biopsy showing caseous necrosis, Langhans giant cells, and epithelioid cells
No polymorphonuclear neutrophils and no caseous necrosis were observed (Figures 1 and 2).
All cases fulfilled the clinical criteria according to Chinese Society of Gastroenterology :[sup][5] (1) histological biopsy showed epithelioid granuloma with caseous necrosis in intestinal tissue or mesenteric lymph nodes; (2) intestinal tissue biopsy was positive for MTB on culture or acid-fast stain; (3) patients showed a good response to anti-TB therapy with clinical manifestation consistent with active TB.
Isolated peripancreatic lymph nodes also showed epithelioid cell granulomas with caseous necrosis. Ziehl Neelsen staining revealed the presence of acid-fast bacilli in the necrotic areas [Figure 5, inset].
The classical picture of histopathology of the lymph nodes is a granulomatous lesion with caseous necrosis and numerous epitheloid cells, lymphocytes, plasma cells, and fibroblasts and Langerhans type of multinucleated giant cells.16 The two histological features which specifically point towards the diagnosis of tuberculosis are variation in the size of the granulomata and the presence of caseation necrosis.