cascade


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cascade

 [kas-kād´]
a series of steps or stages (as of a physiological process) that, once initiated, continues to the final step because each step is triggered by the preceding one, resulting in amplification of the signal, information, or effect at each stage. In electronics, the term is applied to multiple amplifiers. Examples in biochemistry include blood coagulation and the complement system.
coagulation cascade the series of steps beginning with activation of the intrinsic or extrinsic pathways of coagulation, or of one of the related alternative pathways, and proceeding through the common pathway of coagulation to the formation of the fibrin clot.
The coagulation cascade. This scheme emphasizes the understanding of 1, the importance of the tissue factor pathway in initiating clotting in vivo; 2, the interactions between pathways; and 3, the pivotal role of thrombin in sustaining the cascade by feedback activation of coagulation factors. HMWK = high-molecular-weight kininogen; PK = prekallikrein; PL = phospholipid; PT = prothrombin; TF = tissue factor; Th = thrombin. From Schafer, 1994.

cas·cade

(kas-kād'),
1. A series of sequential interactions, as of a physiologic process, which after being initiated continues to the final one; each interaction is activated by the preceding one, sometimes with cumulative effect.
2. To spill over, especially rapidly.
[Fr., fr. It. cascare, to fall]

cascade

(kăs-kād′)
n.
a. A succession of stages, processes, operations, or units.
b. Electronics A series of components or networks, the output of each of which serves as the input for the next.
c. A chemical or physiological process that occurs in successive stages, each of which is dependent on the preceding one, and often producing a cumulative effect: an enzymatic cascade.
Cardiac Arrest in Seattle: Conventional vs. Amiodarone Drug Evaluation. A trial comparing conventional therapy vs. amiodarone, an antiarrhythmic on M&M in survivors of refractory out-of-hospital ventricular arrhythmias
Conclusion Slight increase in survival free of cardiac death; resuscitated ventricular fibrillation or defibrillator shock was better with amiodarone at 2, 4, and 6 years of followup; overall mortality is high, side effects are common

cascade

Physiology A molecular system capable of self-propagation or amplification, especially of a weak signal; once a cascade is initiated, it may continue to be amplified through positive feedback loops and pathways, until down-regulated by local mechanisms–eg, by proteolytic enzymes. See Complement cascade, Ischemic cascade, Metastatic cascade.

CASCADE

Cardiology A clinical trial–Cardiac Arrest in Seattle: Conventional vs Amiodarone Drug Evaluation–that compared conventional therapy vs amiodarone, an antiarrhythmic on M&M in survivors of refractory out-of-hospital ventricular arrhythmias. See Amiodarone, Ventricular arrhythmia. Cf BASIS.

cas·cade

(kas-kād')
1. A series of sequential interactions, as of a physiologic process, which after being initiated continues to the final one; each interaction is activated by the preceding one, sometimes with cumulative effect.
2. To spill over, especially rapidly.
[Fr., fr. It. cascare, to fall]

cascade

A physiological system in which the completion of one event has an outcome that initiates the next successive event. Blood coagulation, for instance, is a cascade involving more than a dozen successive events. In genetics a cascade system controls the order in which genes are expressed.

cascade

sequential ENZYME reactions in which one activated enzyme activates the next in the sequence, which in turn amplifies the initial response, as in the COMPLEMENT system and BLOOD CLOTTING.
References in periodicals archive ?
Additional Cascade program details are available at www.cascadetraining.com.
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However, the above indicator evaluates the network ability of resisting cascade failures only in terms of the number of survived nodes in the network.
served as exclusive financial advisor and Hunton & Williams LLP served as legal counsel to Cascade.
The system conversion and merger of the two banks is scheduled to commence on Friday, August 11, 2017, and Bank of the Cascades will officially operate as First Interstate Bank on Monday, August 14.
The addition of Cascade Networks adds another aggregation point for Wave's customers, and expands the type and depth of services Cascade's customers can leverage for their businesses.
Denis Ripley, chairman of the Friends group, said he was delighted the Cascade was now flowing again and added: "Unlike the Victorians, who were dependent on rainfall to make the water flow, we can now guarantee a cascade from 10am - 4pm each day!
The acquisition of Prime Pacific by Cascade is subject to customary conditions, including the approval of Prime Pacific's shareholders and bank regulatory authorities, and is expected to close in the third quarter of 2016.
Then the hosts took the lead with a sloppy defensive error by Nelson but well finished by the Cascade striker.
Deep in the Willamette Valley, at Sodbuster Hop Farms, there is an entire field of Salmon Safe Cascade hops that are grown especially for Full Sail.
The Institute for Science and International Security said on its website that Iran was now using a second set, or "cascade," of centrifuge machines at its Natanz pilot plant.
In the newest version, Cascade 8.3, Riverbed will provide out-of-the box WAN optimization intelligence, with an enhanced level of automation, ease-of-use, and consolidated enterprise visibility in one place.