cartilage oligomeric matrix protein


Also found in: Acronyms, Wikipedia.

cartilage oligomeric matrix protein

a member of the trombospondin gene family, it is expressed at high levels in the matrix of chondrocytes. Mutations in the cartilage oligomeric matrix protein gene, COMP, [MIM*600310], result in pseudoachondroplasia and multiple epiphysial dysplasia.
References in periodicals archive ?
Small fragments of cartilage oligomeric matrix protein in synovial fluid and serum as markers for cartilage degradation.
Novel cartilage oligomeric matrix protein (COMP) neoepitopes identified in synovial fluids from patients with joint diseases using affinity chromatography and mass spectrometry.
Aggrecan and cartilage oligomeric matrix protein in serum and synovial fluid of patients with knee osteoarthritis.
(1998) Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts.
(2009) Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race.
Howell et al., "Inhibition of ADAMTS7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin, " Osteoarthritis and Cartilage, vol.
King et al., "Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene, " Nature Genetics, vol.
We found that, 22 days after disease onset, mice immunized with type II collagen had 1.5- to 1.8-fold higher concentrations of urinary deoxypyridinoline, serum RatLaps and serum cartilage oligomeric matrix protein than did control non-immunized mice (Fig.
Retention of cartilage oligomeric matrix protein (COMP) and cell death in redifferentiated pseudoachondroplasia chondrocytes.
Crowder et al., "Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia," Nature Genetics, vol.
Hecht, "Expression of mutant cartilage oligomeric matrix protein in human chondrocytes induces the pseudoachondroplasia phenotype," Journal of Orthopaedic Research, vol.
Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis.

Full browser ?