HBsAg-S gene has been applied as a large carrier molecule
to improve the immunogenicity of DNA vaccines (Gonzalez et al., 2009; Kotiw et al., 2012).
Stellar Biotechnologies Inc is the leader in sustainable manufacture of Keyhole Limpet Hemocyanin (KLH), an immune-stimulating protein utilized as a carrier molecule
in therapeutic vaccine pipelines (targeting cancers, immune disorders, Alzheimer's and inflammatory diseases) and for assessing immune system function.
Oakes, Stellar's Chairman of the Board, President and CEO: "We would like to extend our congratulations to Neovacs on the encouraging results achieved in its Phase 2b study and on the continuing advancement of their IFN-Alpha-Kinoid immunotherapy in systemic lupus erythematosus, which the Lupus Foundation has described as 'one of the world's cruelest, most unpredictable and devastating diseases.' In addition to achieving key endpoints, Neovacs reported potent and long-lasting biological activity of their therapeutic vaccine, which utilizes Stellar KLH as a carrier molecule
. The KLH-conjugated vaccine also demonstrated a favorable safety profile among study participants.
It may be possible to produce high-antibody titers against hapten-structured proteins without using any protein carrier molecule
when using alternative adjuvant systems.
Along with ADP, the anticancer response of a PS can further be enhanced using a carrier molecule
. Carrier molecules
in the form of nanoparticles (NPs) can accumulate in a tumour because of the well-known enhanced permeability retention (EPR) effect.
Investigators have succeeded in reducing relative mRNA expression and mitigating disease phenotypes through either high-dose siRNA administration without a carrier molecule
or using lower doses bound to nanoparticles [15-18].
The free carrier molecule
(L) diffuses back through the liquid membrane phase towards feed membrane interface and again forms the complex.
Like cocaine, MDPV clogs the ports in the carrier molecule
so dopamine can't be mopped up once it has done its job, Baumann and colleagues reported in 2013 in Neuropsychopharmacology.
The nanodrugs use nanoparticle materials such as liposomes (imitation cell membrane) and albumin (a carrier molecule
of the body) as nano-scale drug containers and vectors, to be injected into the bloodstream.
A popular approach is called the "conjugation technique," which links the polysaccharide molecule to a protein carrier molecule
. It's also in this area that Monteiro's skills as a chemist come to the fore.
Strikingly, he has identified vitamin K2, which is known for its role in bone formation and blood clotting, as a novel mitochondrial electron carrier molecule
that is required to maintain high levels of mitochondrial activity and neurotransmitter release.