carnitine


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to carnitine: Carnitine deficiency, acetyl l-carnitine

carnitine

 [kahr´nĭ-tēn]
a derivative of betaine found in skeletal muscle and liver; it is necessary for the mitochondrial oxidation of fatty acids.

car·ni·tine

(kar'ni-tēn),
A trimethylammonium (betaine) derivative of γ-amino-β-hydroxybutyrate, formed from Nε,Nε,Nε-trimethyllysine and from γ-butyrobetaine; the l-isomer is a thyroid inhibitor found in muscle, liver, and meat extract; l-carnitine is an acyl carrier with respect to the mitochondrial membrane and thus stimulates fatty acid oxidation.
Synonym(s): BT factor, vitamin BT
[L. caro carn-, flesh + ine]

carnitine

/car·ni·tine/ (kahr´nĭ-tēn) a betaine derivative involved in the transport of fatty acids into mitochondria, where they are metabolized.

carnitine

(kär′nĭ-tēn′)
n.
A compound that functions in fatty acid metabolism by transporting fatty acids into mitochondria for energy production. It is naturally produced in the body and is present in many animal products, especially red meat. It is also sold as a dietary supplement for its purported health benefits.

carnitine

[kär′nitin]
a substance found in skeletal and cardiac muscle and certain other tissues that functions as a carrier of fatty acids across the membranes of the mitochondria. It is used therapeutically in treating angina and certain deficiency diseases, particularly endocardial fibroelastosis, and as an antithyroid agent. It has actions that closely resemble those of amino acids and B vitamins.

carnitine

Chemistry
An essential amino acid that transports long-chain fatty acids across the inner mitochondrial membrane for breakdown to CO2 or ketone bodies; it acts as an acyl (fatty acid carrier). Carnitine is endogenous (synthesised in the liver and kidneys from lysine and methionine) or exogenous (from red meat and dairy products).

Fringe nutrition
Carnitine allegedly enhances athletic performance, prevents heart disease, controls weight and has anti-ageing properties; current data does not support these assertions.

car·ni·tine

(kahr'ni-tēn)
A trimethylammonium (betaine) derivative of gamma-amino-beta-hydroxybutyric acid, formed from NE,NE,NE -trimethyllsine and from gamma-butyrobetaine; the l-isomer is a thyroid inhibitor found in muscle, liver, and meat extracts; l-carnitine is an acyl carrier with respect to the mitochondrial membrane; it thus stimulates fatty acid oxidation.
[G. karnin, an alkali derived from meat]

carnitine (kärˑ·n·tēn),

n an amino acid found in meat, dairy sources, avocados, tempeh, and wheat. Claimed to be helpful in endurance and congestive heart failure. Often used by body builders.

car·ni·tine

(kahr'ni-tēn)
Compound found in dairy and meat that stimulates fatty acid oxidation.
[G. karnin, an alkali derived from meat]

carnitine (kar´nətēn´),

n a compound found naturally in red meat and dairy, as well as in legumes and nuts, this quaternary ammonium compound assists in the movement of fatty acids through the membrane of the mitochondria.

carnitine

coenzyme of fatty acid oxidation and acetyl transfer; often designated vitamin BT, due to its vitamin role in Tenebrio sp. Present in high concentrations (5% dry weight) in meat extracts.

carnitine acetyltransferase
enzyme associated with buffering of acetyl groups from acetyl CoA.
carnitine deficiency
associated with myocardial disease in dogs, particularly Boxers.
References in periodicals archive ?
Genetic parameters of carnitine, creatine, creatinine, carnosine, and anserine concentration in longissimus muscle and their association with palatability traits in Angus cattle.
Further, the research found that a carnitine high diet promoted the growth of the bacteria, which metabolize carnitine, compounding the problem by producing even more of TMAO.
Life Extension[R] has thoroughly analyzed the report used by the media to attack carnitine, reviewed the published literature on carnitine and heart disease, and conducted a survey of our members using carnitine.
Carnitine is an ammonium compound formed (biosynthesized) from the amino acids lysine and methionine.
The researchers found that increased carnitine levels in patients predicted increased risks for cardiovascular disease and major cardiac events like heart attack, stroke and death, but only in subjects with concurrently high TMAO levels.
The distribution of carnitine and acetylcarnitine in the rabbit epididymis and the carnitine content of rabbit spermatozoa during maturation.
Carnitine is made in the liver and recycled by the kidney, but in some cases when this is insufficient, dietary carnitine from red meat and other animal foods can compensate for the shortfall.
If carnitine is the problem, treatment with carnitine supplements can produce dramatic results.
Defects in the maternal carnitine transporter have also been detected by low concentrations of carnitine on a newborn screen (6).
Carnitine promotes energy utilization and is important for tissues with high energy requirements (Chiu et al.
The epididymis has the highest carnitine concentration found in body.
Tokyo, Japan, June 15, 2006 - (JCN) - Nisshin OillliO has announced the results of its latest research on Renacare Carnitine Jelly, a health food for kidney disease patients developed by Nisshin Science.