carisoprodol


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Related to carisoprodol: cyclobenzaprine, Tramadol

carisoprodol

 [kar″i-so´pro-dol]
an analgesic and skeletal muscle relaxant used to relieve symptoms of acute painful skeletomuscular disorders, administered orally.

carisoprodol

Soma

Pharmacologic class: Carbamate derivative

Therapeutic class: Centrally acting skeletal muscle relaxant

Controlled substance schedule IV (in some states)

Pregnancy risk category C

Action

Unknown. May modify central perception of pain without modifying pain reflexes. Skeletal muscle relaxation may result from sedative properties or from inhibition of activity in descending reticular formation and spinal cord.

Availability

Tablets: 250 mg, 350 mg

Indications and dosages

Adjunctive treatment of muscle spasms associated with acute painful musculoskeletal conditions

Adults: 350 mg P.O. q.i.d.

Relief of discomfort associated with acute painful musculoskeletal conditions

Adults: 250 to 350 mg P.O. t.i.d. and at bedtime

Contraindications

• Hypersensitivity to drug or meprobamate
• Porphyria or suspected porphyria

Precautions

Use cautiously in:
• severe hepatic or renal disease
• history of substance abuse
• pregnant or breastfeeding patients
• children ages 12 and younger.

Administration

• Give last daily dose at bedtime.
• Administer with food if GI upset occurs.
• If patient can't swallow tablets, mix with syrup, chocolate, or jelly.

Adverse reactions

CNS: dizziness, drowsiness, agitation, ataxia, depression, headache, insomnia, vertigo, tremor, depression

CV: hypotension, tachycardia

GI: nausea, vomiting, epigastric distress

Hematologic: eosinophilia, leukopenia

Respiratory: asthma attacks

Skin: flushing (especially of face), rash, pruritus, erythema multiforme

Other: hiccups, fever, psychological drug dependence, anaphylactic shock

Interactions

Drug-drug.Antihistamines, opioids, sedative-hypnotics: additive CNS depression

Drug-diagnostic tests.Eosinophils: increased count

Drug-herbs.Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors.Alcohol use: increased CNS depression

Patient monitoring

• When giving to breastfeeding patient, watch for signs of sedation and GI upset in infant.
• Monitor range of motion, stiffness, and discomfort level.
• Know that drug is metabolized to meprobamate. Monitor for drug dependence, especially in patients with history of substance abuse.

Patient teaching

• Tell patient that psychological drug dependence may occur.
• Instruct patient to avoid over-the-counter drugs and alcohol, because they may increase CNS depression.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

carisoprodol

/car·iso·pro·dol/ (kar″i-so-pro´dol) an analgesic and skeletal muscle relaxant used to relieve symptoms of acute painful skeletomuscular disorders.

carisoprodol

[ker′isōprō′dol]
a skeletal muscle relaxant.
indication It is prescribed for the relief of muscle spasm.
contraindications Porphyria or known hypersensitivity to this drug or to chemically similar drugs, such as meprobamate, prohibits its use.
adverse effects Among the more serious adverse reactions are ataxia, drowsiness, pronounced weakness, visual disturbances, mental confusion, anaphylactic shock, erythema multiforme, and allergic reactions.

carisoprodol

Rela® Pharmacology A muscle relaxant related to meprobamate. See Meprobamate.

carisoprodol

A centrally-acting muscle relaxant drug used in the treatment of muscle spasms. A brand name is Carisoma.

carisoprodol (ker´īsōprō´dol),

n brand names: Soma, Vanasom;
drug class: skeletal muscle relaxant, central acting;
action: nonspecific central nervous system sedation;
uses: adjunct for relief of muscle spasm in musculoskeletal conditions.
References in periodicals archive ?
The company's Carisoprodol and Aspirin Tablets are used to relieve pain, muscle spasm and limited mobility associated with acute painful musculoskeletal conditions.
The AS (Ashworth, 1964) was originally developed to assess responsiveness to treatment of spasticity to treatment with carisoprodol in multiple sclerosis.
Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cy-clobenzaprine hydrochloride, and metaxalone.
Also missing were 415 Carisoprodol pills, 33 Robaxin, 79 Topomax/Klonopin and 24 diuretics/antibiotics - although it is not clear whether she had downed them all.
En esta linea esta Dorsal, una de las recientes innovaciones en medicina que es segura, eficaz y que reune el antiinflamatorio meloxicam y el relajante muscular carisoprodol.
RANK COST DRUG NAME 2003 2002 INCREASE * Oxycontin 1 1 15% Neurontin 2 3 12% Celebrex 3 2 12% Hydroco/Apap 4 5 12% Vioxx 5 4 6% Duragesic 6 6 14% Bextra 7 11 33% Carisoprodol 8 7 8% Ambien 9 9 14% Skelaxin 10 13 29% Lidoderm 11 22 12% Tizanidine 12 37 60% Cyclobenzapr 13 12 11% Tramadol Hcl 14 35 30% Actiq 15 32 55% Ultracet 16 19 23% Percocet 17 21 30% Ranitidine 18 27 26% Propo-N/Apap 19 14 -3% Effexor Xr 20 17 13% Naproxen 21 16 17% Topamax 22 24 22% Morphine Sul 23 29 -1% Zoloft 24 18 6% Wellbutrin 25 31 3% Sub-Total Top 25 12% * Change in the average prescription cost in the calendar year for claimants receiving the drug.
The ingredient's ability to inhibit the spontaneous contraction of muscle cells was evaluated by measuring the frequency of contractions over 24 hours using Carisoprodol, a known muscle relaxant, as a positive control.
Places the drug carisoprodol, a prescription muscle-relaxant, under Schedule IV of the drug schedules, therefore making the drug a "controlled" substance.
Carisoprodol is metabolized in the liver by CYP-450 2C19 to an active metabolite, meprobamate.
Drewes has found plenty of chemicals in treated wastewater--an antibiotic, a chemical used in perfume production, the muscle relaxant drug carisoprodol, and its metabolite meprobamate, among others.
For example, carisoprodol is a commonly abused and readily available prescription medication that is sold as a street drug.
Muscle relaxants, such as cyclobenzaprine (Flexeril[R]), methocarbamol (Robaxin[R]) and carisoprodol (Soma[R]) often are used in tandem with alcohol ("hooch") to produce significant highs.