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a·tri·al na·tri·u·ret·ic pep·tide (ANP),
a 28-amino acid peptide (α-ANP) derived from cardiac atria, several smaller fragments of α-ANP, and a dimer of α-ANP with 56 amino acids (β-ANP) that are present in plasma in heart failure. Among other actions, ANP promotes renal salt and water excretion, increases capillary function, and decreases arterial pressure and the secretion of renin, angiotensin, aldosterone, and antidiuretic hormone.
NPPAA gene on chromosome 1p36.21 that encodes a member of the natriuretic peptide family, which control extracellular fluid volume and electrolyte homeostasis.
NPPA mutations are associated with atrial fibrillation familial type 6.