of cardiac fibroblasts by adenoviral delivery of MyoD ex vivo: an unlimited source of cells for myocardial repair.
An alternative to surgical treatment is cardiomyoplasty
, a skeletal muscle transplant to the area around the heart.
with human amniotic fluid stem cells: In vitro and in vivo studies.
Among the various treatment options for a silent heart attack are angioplasty (a special tubing with an attached deflated balloon is threaded up to the coronary arteries); artificial heart valve surgery (abnormal or diseased heart valve is replaced with a healthy one); bypass surgery (treats blocked heart arteries by creating new passages for blood to flow to the heart muscle); cardiomyoplasty
; and heart transplant (diseased heart is removed and replaced with a donated healthy human heart).
Berlin et al., "The use of gadolinium-carbon nanostructures to magnetically enhance stem cell retention for cellular cardiomyoplasty
," Biomaterials, vol.
In the ABCD trial (percutaneous intracoronary cellular cardiomyoplasty
for nonischemic cardiomyopathy; NCT unavailable), 44 patients with nonischemic HF received either intracoronary injection of BMMC (24 patients) or sham infusion without stem cells (20 patients).
Sakakida et al., "Tissue cardiomyoplasty
using bioengineered contractile cardiomyocyte sheets to repair damaged myocardium: their integration with recipient myocardium," Transplantation, vol.
At the very beginning of cardiac tissue engineering, the idea of the injection of multipotent cells into the infarcted myocardium, termed cellular cardiomyoplasty
, was developed as an alternative therapeutic strategy for end stage HF or cardiomyopathy [7-9].
Coverage includes the tools and techniques of minimally invasive coronary artery bypass surgery, aortic valve repair, arrhythmia surgery, cellular cardiomyoplasty
and stem cell therapy, and mechanical circulatory support, among other topics.
Kao, "Cellular cardiomyoplasty
: myocardial regeneration with satellite cell implantation," Annals of Thoracic Surgery, vol.
," Bulletin of Transplantology and Artifical Organs, No2, pp.53-62.
"If we could immortalize embryonic stem cells," West says, "we could potentially repair the human heart, for example, after a heart attack, making young heart muscle by injecting these primitive cells into the heart to regenerate damaged tissue." That was an astonishingly prescient vision because we're already seeing clinical trials using this technique (cardiomyoplasty
) in humans.