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Related to cardiolipin: Lupus anticoagulant

car·di·o·lip·in (CL),

A 1,3-bis(phosphatidyl)glycerol found in many biomembranes with immunologic properties; used in serologic diagnosis of syphilis. When mixed with lecithin and cholesterol cardiolipin will combine with the Wassermann antibody but not with the treponema-immobilizing antibody.
Farlex Partner Medical Dictionary © Farlex 2012


A phospholipid usually obtained from beef heart, used in combination with phosphatidylcholine and cholesterol as an antigen to diagnose syphilis.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


A 1,3-bis(phosphatidyl)glycerol found in many biomembranes with immunologic properties; used in serologic diagnosis of syphilis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


A substance derived from beef heart muscle and once much used in the WASSERMAN REACTION test for SYPHILIS. Current interest is focused on immunoglobulins known as anticardiolipin antibodies.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Patient discussion about cardiolipin

Q. what is anh cardiolipin antibody

A. Cardiolipin is a protein that is very common in the body. Mostly on heart and skeletal muscles. During several illnesses, mostly autoimmune, our body creates an antibody against it that do great damage and needs to cbe controlled.

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References in periodicals archive ?
Venereal Disease Research Laboratory (VDRL): The VDRL uses the modified cardiolipin antigen as a target.
10N-nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria.
Cardiolipin regulates the activity of reconstituted mitochonddal caicium importer by modifying the structure of the liposome bilayer.
Faria et al., "Cytochrome c-promoted cardiolipin oxidation generates singlet molecular oxygen," Photochemical & Photobiological Sciences, vol.
Gluing the respiratory chain together: cardiolipin is required for supercomplex formation in the inner mitochondrial membrane.
ANA, anti- ds DNA antibodies, lupus anticoagulant, anti- cardiolipin antibodiesand Coombs direct and indirect test were negative.
Results: Pretreatment of MC3T3-E1 cells with paeoniflorin prevented the MG-induced cell death and formation of intracellular reactive oxygen species, cardiolipin peroxidation, and protein adduct in osteoblastic MC3T3-E1 cells.
Results suggest that these dietary supplements are able to increase oxidative damage in brain cortex and hippocampus (with a substantial increment of the lipoperoxides and conjugated dienes in the cardiolipin subfraction), increase the proportion Cho/phospholipids, and consequently decrease the concentration of mGSH, decrease the membrane potential, modify the proportion of cardiolipin and lyso-derivatives, alter inner and outer mitochondrial membrane fluidities, and increase A[beta](1-42)/(1-40) ratio.
A hypercoagulable workup (protein C, protein S, factor II mutation, antithrombin III level, lupus anticoagulant, MTHFR mutation, cryoglobulin, homocystine, cardiolipin antibody, lipoprotein (a), beta-2 glycoprotein) showed abnormality of Factor V Leiden with heterozygousity for R506Q polymorphism.
Rheumatic heart disease patients demonstrated higher occurrence of antibodies to cardiolipin [16, 17], however, immunoglobulin G and M antibodies to cardiolipin increased significantly with disease activity [17].
It's a complex driven by cardiolipin, which re-energizes the skin and boosts its natural ability to repair.
(8) This is explained by the presence of cardiolipin (phospholipid) in the Venereal Disease Research Laboratory test reagent.