A growing body of research suggests that overproduction of nitric oxide inside heart and blood vessel cells following a heart attack may play a critical role in the development of cardiogenic
The American College of Cardiology and the American Heart Association revised their guidelines in 1999, elevating early mechanical intervention for cardiogenic
shock to a class I recommendation for patients younger than 75 with an ST-elevation left bundle-branch block acute MI.
Shock Therapeutics under Investigation by Universities/Institutes
The present retrospective cohort study involved 142 patients with severe acute cardiogenic
pulmonary oedema who were admitted to coronary care or the intensive care unit of a university hospital and were treated by an in-hospital protocol.
shock is a state of inadequate bloodflow to the body's tissue caused by the failure of the heart to pump effectively, most commonly following acute myocardial infarction (heart attack).
We are particularly pleased by receiving this designation in Europe because of the pioneering role European investigators are playing in the development of TAI for the management of cardiogenic
shock," said Kenneth E.
2] to predict the status of the cardiac output may be different in patients with cardiogenic
shock (ischaemic hypoxia) or septic shock (cytotoxic hypoxia), sensitivity analysis was performed with data from the patients with cardiogenic
shock only (17).
TRIUMPH (Tilarginine Acetate for Injection in a Randomized International Study in Unstable AMI Patients with Cardiogenic
Shock) will evaluate the effectiveness of TAI to reduce all cause mortality in patients with CS.
Shock Class I: Recommendation: "A hemodynamic support device is recommended for patients with cardiogenic
shock after STEMI who do not quickly stabilize with pharmacological therapy (384,424-427).
This is the largest reported paper on AMI cardiogenic
shock patients on VAD support.
Arginox is addressing an area of significant unmet medical need in cardiology: cardiogenic
shock, a deadly complication of heart attack, which has not been tackled despite other advances in acute cardiac care," said Dr.
Food and Drug Administration (FDA) has granted orphan drug designation to Tilarginine Acetate Injection (TAI) for the treatment of cardiogenic