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At the end of the treatment period, all surviving doves were anesthetized with an intramuscular injection of ketamine/xylazine and euthanatized by exsanguination by cardiocentesis. Postmortem examination was done within 4 hours of euthanasia.
In late stages of HIV infection screening for autonomic dysfunction may be advisable before invasive procedures such as peri cardiocentesis because of risk of cardiovascular collapse or sudden death.
In soft shell turtles, cardiocentesis can be performed for blood collection (Figure 15-29).
The single-dose study reported a macroscopic observation of the thymus of one male rat in the control dose group presenting as "discolored red." Microscopically, this presented with hemorrhage and was considered an incidental finding, possibly related to terminal cardiocentesis. No other microscopic changes were observed.