cardinal

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car·di·nal

(kar'di-năl),
Chief or principal; in embryology, relating to the main venous drainage.
[L. cardinalis, principal]

CARD8

A gene on chromosome 19q13.33 that encodes a protein involved in apoptosis which is highly expressed in the lung, ovary, testis and placenta. CARD8 inhibits NF-kappa-B activation and regulates cell responses controlled by NF-kappa-B transcription factor. It may be part of the inflammasome, a protein complex that activates proinflammatory caspases.