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Chief or principal; in embryology, relating to the main venous drainage.
[L. cardinalis, principal]
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 19q13.33 that encodes a protein involved in apoptosis which is highly expressed in the lung, ovary, testis and placenta. CARD8 inhibits NF-kappa-B activation and regulates cell responses controlled by NF-kappa-B transcription factor. It may be part of the inflammasome, a protein complex that activates proinflammatory caspases.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Moving into the seventeenth century, Karin Wolfe and David Marshall describe struggles for power within the Barberini and Patrizi families, who put their elder sons in charge of their households and lined up a Cardinalate for their younger "heir to spare" (or in the case of the Barbarini, for two brothers who became Cardinals and bitter rivals).
In spite of all this, Newman's true greatness was finally acknowledged in 1879 when the venerable father was elevated to the cardinalate by Pope Leo XIII.
The dispersed apostles became archbishops and bishops.(28) The dignity of the cardinalate is greater than any, though as bishop, priest, or deacon the cardinals were ranked in order within it.
In February 2015, Francis made two Italians cardinals but bypassed the traditional cardinalate sees of Venice and Turin.
Pope Alexander VI (1492-1503) was particularly notorious for conferring church benefices upon his illegitimate sons, most famously Cesare Borgia upon whom he bestowed the cardinalate in 1493 (Gervaso 102-13).
Earlier, retired Lingayen-Dagupan Archbishop Oscar Cruz said even if Quevedo submits his resignation, the pontiff might also not accept it because of his elevation to the cardinalate.
Cardinal Gregory first appears in papal records on 7 December, 1190, but we cannot know when he was appointed since papal eschatocols do not preserve subscriptions of men appointed to the Cardinalate, although even this information would not reveal anything more about Gregory (8).
MANILA -- A senior Filipino Roman Catholic prelate is hoping the Vatican will promote a Filipino bishop to the cardinalate soon because the Philippines is now without a representative on the Catholic conclave for the first time since the 1960s.
Benedict also elevated to the Cardinalate Lucian Murescan, Major Archbishop in Romania, and three priests: Julien Rico (Belgium); Prosper Grech (O.S.A.), Rome; and Karl Becker, S.J., Rome.
Generous loans secured profitable papal contracts, and the convergence of family, city, and papal interests led Julius II to bring Bendinello Sauli into the Curia in 1503 and raise him to the Cardinalate in 1511.
Pompeo Colonna was named to the cardinalate by Leo X in late 1517; sometime after his elevation, he commissioned an illuminated missal that remained incomplete at the time of his death in 1532.